Malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement. A case report
Malignant deep brain stimulation (DBS) withdrawal syndrome constitutes a rare neurological emergency among advanced Parkinson's disease (PD) patients treated with the subthalamic nucleus (STN) Deep Brain Stimulation. Its clinical course mimics Neuroleptic Malignant Syndrome and when left untrea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Interdisciplinary Neurosurgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214751923002268 |
| _version_ | 1797259958232809472 |
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| author | Paweł R. Zdunek Victor Mandat Henryk M. Koziara Tomasz S. Mandat |
| author_facet | Paweł R. Zdunek Victor Mandat Henryk M. Koziara Tomasz S. Mandat |
| author_sort | Paweł R. Zdunek |
| collection | DOAJ |
| description | Malignant deep brain stimulation (DBS) withdrawal syndrome constitutes a rare neurological emergency among advanced Parkinson's disease (PD) patients treated with the subthalamic nucleus (STN) Deep Brain Stimulation. Its clinical course mimics Neuroleptic Malignant Syndrome and when left untreated might lead to death.We present a case of a 61 year old woman treated with STN DBS because of PD, who underwent under local anesthesia implantable pulse generator (IPG) replacement. The IPG stopped functioning several days before the replacement. Due to increased motor symptoms the patient was unable to intake medications several days prior to surgical intervention. Within immediate post-operative period she developed malignant DBS withdrawal syndrome. The successful treatment consisted of supportive care, dopaminergic medication and immediate restoration of the IPG. |
| first_indexed | 2024-03-08T15:31:54Z |
| format | Article |
| id | doaj.art-b91de73f0026488ea1ec684a2b9535df |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-04-24T23:17:42Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-b91de73f0026488ea1ec684a2b9535df2024-03-17T07:54:18ZengElsevierInterdisciplinary Neurosurgery2214-75192024-06-0136101943Malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement. A case reportPaweł R. Zdunek0Victor Mandat1Henryk M. Koziara2Tomasz S. Mandat3Department of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, PolandDepartment of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland; University of Toronto, Toronto, CanadaDepartment of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, PolandDepartment of Neurosurgery, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland; Corresponding author.Malignant deep brain stimulation (DBS) withdrawal syndrome constitutes a rare neurological emergency among advanced Parkinson's disease (PD) patients treated with the subthalamic nucleus (STN) Deep Brain Stimulation. Its clinical course mimics Neuroleptic Malignant Syndrome and when left untreated might lead to death.We present a case of a 61 year old woman treated with STN DBS because of PD, who underwent under local anesthesia implantable pulse generator (IPG) replacement. The IPG stopped functioning several days before the replacement. Due to increased motor symptoms the patient was unable to intake medications several days prior to surgical intervention. Within immediate post-operative period she developed malignant DBS withdrawal syndrome. The successful treatment consisted of supportive care, dopaminergic medication and immediate restoration of the IPG.http://www.sciencedirect.com/science/article/pii/S2214751923002268Deep brain stimulationWithdrawal syndromeMalignant neuroleptic syndromeParkinsonism hyperrhexia syndrome |
| spellingShingle | Paweł R. Zdunek Victor Mandat Henryk M. Koziara Tomasz S. Mandat Malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement. A case report Interdisciplinary Neurosurgery Deep brain stimulation Withdrawal syndrome Malignant neuroleptic syndrome Parkinsonism hyperrhexia syndrome |
| title | Malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement. A case report |
| title_full | Malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement. A case report |
| title_fullStr | Malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement. A case report |
| title_full_unstemmed | Malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement. A case report |
| title_short | Malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement. A case report |
| title_sort | malignant deep brain stimulation withdrawal syndrome following elective implantable pulse generator replacement a case report |
| topic | Deep brain stimulation Withdrawal syndrome Malignant neuroleptic syndrome Parkinsonism hyperrhexia syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2214751923002268 |
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