Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model
Background: Rotator cuff tear has become one of the diseases affecting people's living quality. Conventional anchor materials such as titanium alloy and poly-lactic acid can lead to postoperative complications like bone defects and aseptic inflammation. Magnesium (Mg)-based implants are biodegr...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
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Elsevier
2022-07-01
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Series: | Journal of Orthopaedic Translation |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X22000717 |
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author | Yudie Chen Yu Sun Xinhui Wu Jie Lou Xiaonong Zhang Zhaoxiang Peng |
author_facet | Yudie Chen Yu Sun Xinhui Wu Jie Lou Xiaonong Zhang Zhaoxiang Peng |
author_sort | Yudie Chen |
collection | DOAJ |
description | Background: Rotator cuff tear has become one of the diseases affecting people's living quality. Conventional anchor materials such as titanium alloy and poly-lactic acid can lead to postoperative complications like bone defects and aseptic inflammation. Magnesium (Mg)-based implants are biodegradable and biocompatible, with strong potential to be applied in orthopaedics. Methods: In this study, we developed a high-purity (HP) Mg suture anchor and studied its mechanical properties and degradation behavior in vitro. Furthermore, we described the use of high-purity Mg to prepare suture anchor for the rotator cuff repair in sheep. Results: The in vitro tests showed that HP Mg suture anchor possess proper degradation behavior and appropriate mechanical property. Animal experiment indicated that HP Mg suture anchor provided reliable anchoring function in 12 weeks and showed no toxic effect on animal organs. Conclusion: In summary, the HP Mg anchor presented in this study had favorable mechanical property and biosecurity.The translational potential of this article: The translational potential of this article is to use high-purity Mg to develop a degradable suture anchor and verify the feasibility of the application in animal model. This study provides a basis for further research on the clinical application of biodegradable high-purity Mg suture anchor. |
first_indexed | 2024-04-11T23:53:18Z |
format | Article |
id | doaj.art-b91ef71b896e4e55af9365bed9ea4344 |
institution | Directory Open Access Journal |
issn | 2214-031X |
language | English |
last_indexed | 2024-04-11T23:53:18Z |
publishDate | 2022-07-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Orthopaedic Translation |
spelling | doaj.art-b91ef71b896e4e55af9365bed9ea43442022-12-22T03:56:26ZengElsevierJournal of Orthopaedic Translation2214-031X2022-07-01356271Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep modelYudie Chen0Yu Sun1Xinhui Wu2Jie Lou3Xiaonong Zhang4Zhaoxiang Peng5The Affiliated Lihuili Hospital, Ningbo University, Ningbo, 315100, ChinaState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, ChinaThe Affiliated Lihuili Hospital, Ningbo University, Ningbo, 315100, ChinaState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, ChinaState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Suzhou Origin Medical Technology Co. Ltd., Jiangsu, 215513, China; Corresponding author. State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.The Affiliated Lihuili Hospital, Ningbo University, Ningbo, 315100, China; Corresponding author.Background: Rotator cuff tear has become one of the diseases affecting people's living quality. Conventional anchor materials such as titanium alloy and poly-lactic acid can lead to postoperative complications like bone defects and aseptic inflammation. Magnesium (Mg)-based implants are biodegradable and biocompatible, with strong potential to be applied in orthopaedics. Methods: In this study, we developed a high-purity (HP) Mg suture anchor and studied its mechanical properties and degradation behavior in vitro. Furthermore, we described the use of high-purity Mg to prepare suture anchor for the rotator cuff repair in sheep. Results: The in vitro tests showed that HP Mg suture anchor possess proper degradation behavior and appropriate mechanical property. Animal experiment indicated that HP Mg suture anchor provided reliable anchoring function in 12 weeks and showed no toxic effect on animal organs. Conclusion: In summary, the HP Mg anchor presented in this study had favorable mechanical property and biosecurity.The translational potential of this article: The translational potential of this article is to use high-purity Mg to develop a degradable suture anchor and verify the feasibility of the application in animal model. This study provides a basis for further research on the clinical application of biodegradable high-purity Mg suture anchor.http://www.sciencedirect.com/science/article/pii/S2214031X22000717High-purity magnesiumSuture anchorRotator cuff repairSheep model |
spellingShingle | Yudie Chen Yu Sun Xinhui Wu Jie Lou Xiaonong Zhang Zhaoxiang Peng Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model Journal of Orthopaedic Translation High-purity magnesium Suture anchor Rotator cuff repair Sheep model |
title | Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model |
title_full | Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model |
title_fullStr | Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model |
title_full_unstemmed | Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model |
title_short | Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model |
title_sort | rotator cuff repair with biodegradable high purity magnesium suture anchor in sheep model |
topic | High-purity magnesium Suture anchor Rotator cuff repair Sheep model |
url | http://www.sciencedirect.com/science/article/pii/S2214031X22000717 |
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