Anemia Increases Oxygen Extraction Fraction in Deep Brain Structures but Not in the Cerebral Cortex

Anemia Increases Oxygen Extraction Fraction in Deep Brain Structures but Not in the Cerebral Cortex

Sickle cell disease (SCD) is caused by a single amino acid mutation in hemoglobin, causing chronic anemia and neurovascular complications. However, the effects of chronic anemia on oxygen extraction fraction (OEF), especially in deep brain structures, are less well understood. Conflicting OEF values...

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Bibliographic Details
Main Authors:	Jian Shen, Xin Miao, Chau Vu, Botian Xu, Clio González-Zacarías, Aart J. Nederveen, John C. Wood
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Physiology
Subjects:	sickle cell anemia oxygen extraction fraction internal cerebral vein susceptibility QSM CISSCO
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.896006/full

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