Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease
Sustained control of Mycobacterium tuberculosis infection without evidence of disease is based on a finely tuned balance between pro- and anti-inflammatory responses. Loss of this balance leads to tuberculosis (TB) disease, in which exacerbated myeloid and neutrophil activation is common. Proteomic...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224000559 |
| _version_ | 1797213475083124736 |
|---|---|
| author | Gunilla Källenius Margarida Correia-Neves Christopher Sundling |
| author_facet | Gunilla Källenius Margarida Correia-Neves Christopher Sundling |
| author_sort | Gunilla Källenius |
| collection | DOAJ |
| description | Sustained control of Mycobacterium tuberculosis infection without evidence of disease is based on a finely tuned balance between pro- and anti-inflammatory responses. Loss of this balance leads to tuberculosis (TB) disease, in which exacerbated myeloid and neutrophil activation is common. Proteomic and transcriptomic assessment of the host response can detect increasing immune activation associated with TB disease progression several months before clinical disease. Future diagnostic methods based on measuring host response biomarkers that are able to detect this dysregulation could therefore be valuable in the early detection of TB disease progression. |
| first_indexed | 2024-04-24T10:58:52Z |
| format | Article |
| id | doaj.art-b920ef7648604c268da1161562f72885 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-24T10:58:52Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-b920ef7648604c268da1161562f728852024-04-12T04:44:23ZengElsevierInternational Journal of Infectious Diseases1201-97122024-04-01141106984Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis diseaseGunilla Källenius0Margarida Correia-Neves1Christopher Sundling2Division of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, SwedenDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga, PortugalDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Corresponding author.Sustained control of Mycobacterium tuberculosis infection without evidence of disease is based on a finely tuned balance between pro- and anti-inflammatory responses. Loss of this balance leads to tuberculosis (TB) disease, in which exacerbated myeloid and neutrophil activation is common. Proteomic and transcriptomic assessment of the host response can detect increasing immune activation associated with TB disease progression several months before clinical disease. Future diagnostic methods based on measuring host response biomarkers that are able to detect this dysregulation could therefore be valuable in the early detection of TB disease progression.http://www.sciencedirect.com/science/article/pii/S1201971224000559TuberculosisBiomarkersDiagnosticsProteomicsTranscriptomicsImmune response |
| spellingShingle | Gunilla Källenius Margarida Correia-Neves Christopher Sundling Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease International Journal of Infectious Diseases Tuberculosis Biomarkers Diagnostics Proteomics Transcriptomics Immune response |
| title | Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease |
| title_full | Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease |
| title_fullStr | Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease |
| title_full_unstemmed | Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease |
| title_short | Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease |
| title_sort | diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease |
| topic | Tuberculosis Biomarkers Diagnostics Proteomics Transcriptomics Immune response |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224000559 |
| work_keys_str_mv | AT gunillakallenius diagnosticmarkersreflectingdysregulationofthehostresponseinthetransitiontotuberculosisdisease AT margaridacorreianeves diagnosticmarkersreflectingdysregulationofthehostresponseinthetransitiontotuberculosisdisease AT christophersundling diagnosticmarkersreflectingdysregulationofthehostresponseinthetransitiontotuberculosisdisease |