Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics
Targeted therapy is an emerging paradigm in the development of next-generation anticancer drugs. Heat shock factor 1 (HSF1) has been identified as a promising drug target because it regulates several pathways responsible for cancer cell growth, metastasis, and survival. Studies have clearly demonstr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/23/11/2757 |
| _version_ | 1819080142460289024 |
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| author | Chiranjeev Sharma Young Ho Seo |
| author_facet | Chiranjeev Sharma Young Ho Seo |
| author_sort | Chiranjeev Sharma |
| collection | DOAJ |
| description | Targeted therapy is an emerging paradigm in the development of next-generation anticancer drugs. Heat shock factor 1 (HSF1) has been identified as a promising drug target because it regulates several pathways responsible for cancer cell growth, metastasis, and survival. Studies have clearly demonstrated that HSF1 is an effective drug target. Herein, we provide a concise yet comprehensive and integrated overview of progress in developing small molecule inhibitors of HSF1 as next-generation anticancer chemotherapeutics while critically evaluating their potential and challenges. We believe that this review will provide a better understanding of important concepts helpful for outlining the strategy to develop new chemotherapeutic agents with promising anticancer activities by targeting HSF1. |
| first_indexed | 2024-12-21T19:40:11Z |
| format | Article |
| id | doaj.art-b922eb3ce4d44da7901fbe038c2cdf31 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T19:40:11Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b922eb3ce4d44da7901fbe038c2cdf312022-12-21T18:52:30ZengMDPI AGMolecules1420-30492018-10-012311275710.3390/molecules23112757molecules23112757Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer TherapeuticsChiranjeev Sharma0Young Ho Seo1College of Pharmacy, Keimyung University, Daegu 42601, KoreaCollege of Pharmacy, Keimyung University, Daegu 42601, KoreaTargeted therapy is an emerging paradigm in the development of next-generation anticancer drugs. Heat shock factor 1 (HSF1) has been identified as a promising drug target because it regulates several pathways responsible for cancer cell growth, metastasis, and survival. Studies have clearly demonstrated that HSF1 is an effective drug target. Herein, we provide a concise yet comprehensive and integrated overview of progress in developing small molecule inhibitors of HSF1 as next-generation anticancer chemotherapeutics while critically evaluating their potential and challenges. We believe that this review will provide a better understanding of important concepts helpful for outlining the strategy to develop new chemotherapeutic agents with promising anticancer activities by targeting HSF1.https://www.mdpi.com/1420-3049/23/11/2757HSF1HSPsHSF1 inhibitorsanticancer agents |
| spellingShingle | Chiranjeev Sharma Young Ho Seo Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics Molecules HSF1 HSPs HSF1 inhibitors anticancer agents |
| title | Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics |
| title_full | Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics |
| title_fullStr | Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics |
| title_full_unstemmed | Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics |
| title_short | Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics |
| title_sort | small molecule inhibitors of hsf1 activated pathways as potential next generation anticancer therapeutics |
| topic | HSF1 HSPs HSF1 inhibitors anticancer agents |
| url | https://www.mdpi.com/1420-3049/23/11/2757 |
| work_keys_str_mv | AT chiranjeevsharma smallmoleculeinhibitorsofhsf1activatedpathwaysaspotentialnextgenerationanticancertherapeutics AT younghoseo smallmoleculeinhibitorsofhsf1activatedpathwaysaspotentialnextgenerationanticancertherapeutics |