In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia
Malnutrition (MN) is a common primary or secondary complication in gastrointestinal diseases. The patient’s nutritional status also influences muscle mass and function, which can be impaired up to the degree of sarcopenia. The molecular interactions in diseases leading to sarcopenia are complex and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.989453/full |
| _version_ | 1797990123725389824 |
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| author | Matti Hoch Luise Ehlers Karen Bannert Christina Stanke David Brauer Vanessa Caton Georg Lamprecht Olaf Wolkenhauer Olaf Wolkenhauer Olaf Wolkenhauer Robert Jaster Markus Wolfien Markus Wolfien |
| author_facet | Matti Hoch Luise Ehlers Karen Bannert Christina Stanke David Brauer Vanessa Caton Georg Lamprecht Olaf Wolkenhauer Olaf Wolkenhauer Olaf Wolkenhauer Robert Jaster Markus Wolfien Markus Wolfien |
| author_sort | Matti Hoch |
| collection | DOAJ |
| description | Malnutrition (MN) is a common primary or secondary complication in gastrointestinal diseases. The patient’s nutritional status also influences muscle mass and function, which can be impaired up to the degree of sarcopenia. The molecular interactions in diseases leading to sarcopenia are complex and multifaceted, affecting muscle physiology, the intestine (nutrition), and the liver at different levels. Although extensive knowledge of individual molecular factors is available, their regulatory interplay is not yet fully understood. A comprehensive overall picture of pathological mechanisms and resulting phenotypes is lacking. In silico approaches that convert existing knowledge into computationally readable formats can help unravel mechanisms, underlying such complex molecular processes. From public literature, we manually compiled experimental evidence for molecular interactions involved in the development of sarcopenia into a knowledge base, referred to as the Sarcopenia Map. We integrated two diseases, namely liver cirrhosis (LC), and intestinal dysfunction, by considering their effects on nutrition and blood secretome. We demonstrate the performance of our model by successfully simulating the impact of changing dietary frequency, glycogen storage capacity, and disease severity on the carbohydrate and muscle systems. We present the Sarcopenia Map as a publicly available, open-source, and interactive online resource, that links gastrointestinal diseases, MN, and sarcopenia. The map provides tools that allow users to explore the information on the map and perform in silico simulations. |
| first_indexed | 2024-04-11T08:30:23Z |
| format | Article |
| id | doaj.art-b923b6448765496e9df9d1d7f9e4b62a |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T08:30:23Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-b923b6448765496e9df9d1d7f9e4b62a2022-12-22T04:34:32ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.989453989453In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopeniaMatti Hoch0Luise Ehlers1Karen Bannert2Christina Stanke3David Brauer4Vanessa Caton5Georg Lamprecht6Olaf Wolkenhauer7Olaf Wolkenhauer8Olaf Wolkenhauer9Robert Jaster10Markus Wolfien11Markus Wolfien12Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, GermanyDivision of Gastroenterology, Department of Medicine II, Rostock University Medical Center, Rostock, GermanyDivision of Gastroenterology, Department of Medicine II, Rostock University Medical Center, Rostock, GermanyDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, GermanyDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, GermanyDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, GermanyDivision of Gastroenterology, Department of Medicine II, Rostock University Medical Center, Rostock, GermanyDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, GermanyLeibniz-Institute for Food Systems Biology at the Technical University of Munich, Freising, GermanyWallenberg Research Centre, Stellenbosch Institute for Advanced Study, Stellenbosch University, Stellenbosch, South AfricaDivision of Gastroenterology, Department of Medicine II, Rostock University Medical Center, Rostock, GermanyDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, GermanyFaculty of Medicine Carl Gustav Carus, Institute for Medical Informatics and Biometry, Technical University Dresden, Dresden, GermanyMalnutrition (MN) is a common primary or secondary complication in gastrointestinal diseases. The patient’s nutritional status also influences muscle mass and function, which can be impaired up to the degree of sarcopenia. The molecular interactions in diseases leading to sarcopenia are complex and multifaceted, affecting muscle physiology, the intestine (nutrition), and the liver at different levels. Although extensive knowledge of individual molecular factors is available, their regulatory interplay is not yet fully understood. A comprehensive overall picture of pathological mechanisms and resulting phenotypes is lacking. In silico approaches that convert existing knowledge into computationally readable formats can help unravel mechanisms, underlying such complex molecular processes. From public literature, we manually compiled experimental evidence for molecular interactions involved in the development of sarcopenia into a knowledge base, referred to as the Sarcopenia Map. We integrated two diseases, namely liver cirrhosis (LC), and intestinal dysfunction, by considering their effects on nutrition and blood secretome. We demonstrate the performance of our model by successfully simulating the impact of changing dietary frequency, glycogen storage capacity, and disease severity on the carbohydrate and muscle systems. We present the Sarcopenia Map as a publicly available, open-source, and interactive online resource, that links gastrointestinal diseases, MN, and sarcopenia. The map provides tools that allow users to explore the information on the map and perform in silico simulations.https://www.frontiersin.org/articles/10.3389/fnut.2022.989453/fullsarcopeniamalnutritiongastrointestinal diseasessystems biologynetwork modeling |
| spellingShingle | Matti Hoch Luise Ehlers Karen Bannert Christina Stanke David Brauer Vanessa Caton Georg Lamprecht Olaf Wolkenhauer Olaf Wolkenhauer Olaf Wolkenhauer Robert Jaster Markus Wolfien Markus Wolfien In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia Frontiers in Nutrition sarcopenia malnutrition gastrointestinal diseases systems biology network modeling |
| title | In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia |
| title_full | In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia |
| title_fullStr | In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia |
| title_full_unstemmed | In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia |
| title_short | In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia |
| title_sort | in silico investigation of molecular networks linking gastrointestinal diseases malnutrition and sarcopenia |
| topic | sarcopenia malnutrition gastrointestinal diseases systems biology network modeling |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.989453/full |
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