IL-12B Promoter Polymorphism Associated with Asthma and IL-12B Transcriptional Activity

IL-12B Promoter Polymorphism Associated with Asthma and IL-12B Transcriptional Activity

Background: The interleukin-12B gene (IL-12B) encodes the p40 chain of interleukin-12 (IL-12), which promotes cell-mediated Th1 responses and the production of interferon-gamma (IFN-γ) that downregulates IgE production. Chromosome 5q31-q33 near the IL-12B locus is significantly linked to asthma, as...

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Bibliographic Details
Main Authors:	Koji Tatebayashi, Eiko Matsui, Hideo Kaneko, Toshiyuki Fukao, Kimiko Kasahara, Naomi Kondo
Format:	Article
Language:	English
Published:	Elsevier 2005-01-01
Series:	Allergology International
Subjects:	asthma IgE interferon-gamma interleukin-12B promoter polymorphism
Online Access:	http://www.sciencedirect.com/science/article/pii/S1323893015310583

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