Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies
Polymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes such as MTHFR, MTR, CUBN, and SLC19A1 in pregnant wome...
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/13/2702 |
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| author | Gemma Rodriguez-Carnero Paula M. Lorenzo Ana Canton-Blanco Leire Mendizabal Maddi Arregi Mirella Zulueta Laureano Simon Manuel Macia-Cortiñas Felipe F. Casanueva Ana B. Crujeiras |
| author_facet | Gemma Rodriguez-Carnero Paula M. Lorenzo Ana Canton-Blanco Leire Mendizabal Maddi Arregi Mirella Zulueta Laureano Simon Manuel Macia-Cortiñas Felipe F. Casanueva Ana B. Crujeiras |
| author_sort | Gemma Rodriguez-Carnero |
| collection | DOAJ |
| description | Polymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes such as MTHFR, MTR, CUBN, and SLC19A1 in pregnant women of a homogeneous Spanish population according to conception, pregnancy, delivery, and newborns complications. This study was conducted on 149 nulliparous women with singleton pregnancies. Sociodemographic and obstetrics variables were recorded, and all patients were genotyped in the MTHFR, MTR, CUBN, and SLC10A1 polymorphisms. The distribution of genotypes detected in this cohort was similar to the population distribution reported in Europe, highlighting that more than 50% of women were carriers of risk alleles of the studied genes. In women with the MTHFR risk allele, there was a statistically significant higher frequency of assisted fertilisation and a higher frequency of preeclampsia and preterm birth. Moreover, CUBN (rs1801222) polymorphism carriers showed a statistically significantly lower frequency of complications during delivery. In conclusion, the prevalence of genetic variants related to folic acid and vitamin B12 metabolic genes in pregnant women is related to mother and neonatal outcomes. Knowing the prevalence of these polymorphisms may lead to a personalised prescription of vitamin intake. |
| first_indexed | 2024-03-09T03:58:48Z |
| format | Article |
| id | doaj.art-b928842234b5404da4e806ab21d99134 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:58:48Z |
| publishDate | 2022-06-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b928842234b5404da4e806ab21d991342023-12-03T14:16:40ZengMDPI AGNutrients2072-66432022-06-011413270210.3390/nu14132702Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation StrategiesGemma Rodriguez-Carnero0Paula M. Lorenzo1Ana Canton-Blanco2Leire Mendizabal3Maddi Arregi4Mirella Zulueta5Laureano Simon6Manuel Macia-Cortiñas7Felipe F. Casanueva8Ana B. Crujeiras9Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, SpainEpigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, SpainEpigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, SpainPatia Europe, 20009 San Sebastian, SpainPatia Europe, 20009 San Sebastian, SpainPatia Europe, 20009 San Sebastian, SpainPatia Europe, 20009 San Sebastian, SpainGynecology and Obstetrics Division, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, SpainCIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), 28029 Madrid, SpainEpigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), 15706 Santiago de Compostela, SpainPolymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes such as MTHFR, MTR, CUBN, and SLC19A1 in pregnant women of a homogeneous Spanish population according to conception, pregnancy, delivery, and newborns complications. This study was conducted on 149 nulliparous women with singleton pregnancies. Sociodemographic and obstetrics variables were recorded, and all patients were genotyped in the MTHFR, MTR, CUBN, and SLC10A1 polymorphisms. The distribution of genotypes detected in this cohort was similar to the population distribution reported in Europe, highlighting that more than 50% of women were carriers of risk alleles of the studied genes. In women with the MTHFR risk allele, there was a statistically significant higher frequency of assisted fertilisation and a higher frequency of preeclampsia and preterm birth. Moreover, CUBN (rs1801222) polymorphism carriers showed a statistically significantly lower frequency of complications during delivery. In conclusion, the prevalence of genetic variants related to folic acid and vitamin B12 metabolic genes in pregnant women is related to mother and neonatal outcomes. Knowing the prevalence of these polymorphisms may lead to a personalised prescription of vitamin intake.https://www.mdpi.com/2072-6643/14/13/2702vitamin B9vitamin B12pregnancynewbornpolymorphismone-carbon metabolism |
| spellingShingle | Gemma Rodriguez-Carnero Paula M. Lorenzo Ana Canton-Blanco Leire Mendizabal Maddi Arregi Mirella Zulueta Laureano Simon Manuel Macia-Cortiñas Felipe F. Casanueva Ana B. Crujeiras Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies Nutrients vitamin B9 vitamin B12 pregnancy newborn polymorphism one-carbon metabolism |
| title | Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies |
| title_full | Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies |
| title_fullStr | Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies |
| title_full_unstemmed | Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies |
| title_short | Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies |
| title_sort | genetic variants in folate and cobalamin metabolism related genes in pregnant women of a homogeneous spanish population the need for revisiting the current vitamin supplementation strategies |
| topic | vitamin B9 vitamin B12 pregnancy newborn polymorphism one-carbon metabolism |
| url | https://www.mdpi.com/2072-6643/14/13/2702 |
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