Nano-palladium is a cellular catalyst for in vivo chemistry
Palladium (Pd) is a well-known catalyst in organic chemistry but its use in nanomedicine is limited. Here, the authors design a Pd nanoparticle that triggers the activation of an antitumour prodrugin vivo, which shows efficacy and improves toxicity compared to traditional solvent- and nanoparticle-d...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15906 |
| _version_ | 1818990656082673664 |
|---|---|
| author | Miles A. Miller Bjorn Askevold Hannes Mikula Rainer H. Kohler David Pirovich Ralph Weissleder |
| author_facet | Miles A. Miller Bjorn Askevold Hannes Mikula Rainer H. Kohler David Pirovich Ralph Weissleder |
| author_sort | Miles A. Miller |
| collection | DOAJ |
| description | Palladium (Pd) is a well-known catalyst in organic chemistry but its use in nanomedicine is limited. Here, the authors design a Pd nanoparticle that triggers the activation of an antitumour prodrugin vivo, which shows efficacy and improves toxicity compared to traditional solvent- and nanoparticle-drug formulations. |
| first_indexed | 2024-12-20T19:57:50Z |
| format | Article |
| id | doaj.art-b929185b46444f18bedc3e0efd655654 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T19:57:50Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b929185b46444f18bedc3e0efd6556542022-12-21T19:28:08ZengNature PortfolioNature Communications2041-17232017-07-018111310.1038/ncomms15906Nano-palladium is a cellular catalyst for in vivo chemistryMiles A. Miller0Bjorn Askevold1Hannes Mikula2Rainer H. Kohler3David Pirovich4Ralph Weissleder5Center for Systems Biology, Massachusetts General HospitalCenter for Systems Biology, Massachusetts General HospitalCenter for Systems Biology, Massachusetts General HospitalCenter for Systems Biology, Massachusetts General HospitalCenter for Systems Biology, Massachusetts General HospitalCenter for Systems Biology, Massachusetts General HospitalPalladium (Pd) is a well-known catalyst in organic chemistry but its use in nanomedicine is limited. Here, the authors design a Pd nanoparticle that triggers the activation of an antitumour prodrugin vivo, which shows efficacy and improves toxicity compared to traditional solvent- and nanoparticle-drug formulations.https://doi.org/10.1038/ncomms15906 |
| spellingShingle | Miles A. Miller Bjorn Askevold Hannes Mikula Rainer H. Kohler David Pirovich Ralph Weissleder Nano-palladium is a cellular catalyst for in vivo chemistry Nature Communications |
| title | Nano-palladium is a cellular catalyst for in vivo chemistry |
| title_full | Nano-palladium is a cellular catalyst for in vivo chemistry |
| title_fullStr | Nano-palladium is a cellular catalyst for in vivo chemistry |
| title_full_unstemmed | Nano-palladium is a cellular catalyst for in vivo chemistry |
| title_short | Nano-palladium is a cellular catalyst for in vivo chemistry |
| title_sort | nano palladium is a cellular catalyst for in vivo chemistry |
| url | https://doi.org/10.1038/ncomms15906 |
| work_keys_str_mv | AT milesamiller nanopalladiumisacellularcatalystforinvivochemistry AT bjornaskevold nanopalladiumisacellularcatalystforinvivochemistry AT hannesmikula nanopalladiumisacellularcatalystforinvivochemistry AT rainerhkohler nanopalladiumisacellularcatalystforinvivochemistry AT davidpirovich nanopalladiumisacellularcatalystforinvivochemistry AT ralphweissleder nanopalladiumisacellularcatalystforinvivochemistry |