Caffeine Inhibits Oxidative Stress- and Low Dose Endotoxemia-Induced Senescence—Role of Thioredoxin-1

Caffeine Inhibits Oxidative Stress- and Low Dose Endotoxemia-Induced Senescence—Role of Thioredoxin-1

The maintenance of Thioredoxin-1 (Trx-1) levels, and thus of cellular redox homeostasis, is vital for endothelial cells (ECs) to prevent senescence induction. One hallmark of EC functionality, their migratory capacity, which depends on intact mitochondria, is reduced in senescence. Caffeine improves...

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Bibliographic Details
Main Authors: Dennis Merk, Jan Greulich, Annika Vierkant, Fiona Cox, Olaf Eckermann, Florian von Ameln, Nadine Dyballa-Rukes, Joachim Altschmied, Niloofar Ale-Agha, Philipp Jakobs, Judith Haendeler
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Antioxidants
Subjects:
caffeine
endothelial cells (EC)
lipopolysaccharide
senescence
Thioredoxin-1
Online Access:https://www.mdpi.com/2076-3921/12/6/1244

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