| Summary: | The genus <i>Paris</i> is an excellent source of steroidal saponins that exhibit various bioactivities. <i>Paris mairei</i> is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A–E (<b>1</b>–<b>5</b>), along with five known steroidal saponins <b>6</b>–<b>10</b>, were isolated from the rhizomes of <i>Paris mairei</i>. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.
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