Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery
Abstract Background Fatness is an unwanted side effect of genetic selection in broiler chickens. In this study, we introduce mountain celery powder as a feed supplement to suppress lipogenesis and improve antioxidant status in broiler chickens. Male broiler chicks (Ross 308) were fed a control diet...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12917-018-1561-6 |
| _version_ | 1819204906925424640 |
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| author | Behnam Ahmadipour Hossein Hassanpour Fariborz Khajali |
| author_facet | Behnam Ahmadipour Hossein Hassanpour Fariborz Khajali |
| author_sort | Behnam Ahmadipour |
| collection | DOAJ |
| description | Abstract Background Fatness is an unwanted side effect of genetic selection in broiler chickens. In this study, we introduce mountain celery powder as a feed supplement to suppress lipogenesis and improve antioxidant status in broiler chickens. Male broiler chicks (Ross 308) were fed a control diet or a diet that includes mountain celery (MC) at 7.5 gkg−1over 42 days. Results Body weight gain and feed conversion ratio significantly (P < 0.05) improved in chicks fed MC. A highly significant down-regulation of genes involved in hepatic lipogenesis including acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), malic enzyme (ME), and lipoprotein lipase (LPL) was observed in the liver of chickens fed MC. These birds, however, had greater compensatory upregulation in antioxidative genes SOD1 and catalase in the liver compared to the birds that received the control diet. Birds received MC had significantly lower level of lipid peroxidation (1.59 μmol/L serum malondialdehyde) compared to birds from the control group (3.57 μmol/L; P = 0.0024). Birds fed MC had significantly (P < 0.05) lower circulatory concentrations of triacylglycerols, cholesterol, and LDL but higher concentrations of HDL. Relative liver weight and abdominal fat deposition were significantly reduced by feeding MC. Conclusions It can be concluded that feeding birds MC significantly suppresses hepatic lipogenesis by down-regulating key hepatic lipogenic enzyme genes and boosts antioxidant capacity by up-regulating hepatic antioxidantive genes. |
| first_indexed | 2024-12-23T04:43:15Z |
| format | Article |
| id | doaj.art-b929f40fc1154eed9062f471ff75c13a |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-23T04:43:15Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-b929f40fc1154eed9062f471ff75c13a2022-12-21T17:59:43ZengBMCBMC Veterinary Research1746-61482018-08-011411710.1186/s12917-018-1561-6Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celeryBehnam Ahmadipour0Hossein Hassanpour1Fariborz Khajali2Department of Animal Science, Shahrekord UniversityDepartment of Basic Science, Shahrekord UniversityDepartment of Animal Science, Shahrekord UniversityAbstract Background Fatness is an unwanted side effect of genetic selection in broiler chickens. In this study, we introduce mountain celery powder as a feed supplement to suppress lipogenesis and improve antioxidant status in broiler chickens. Male broiler chicks (Ross 308) were fed a control diet or a diet that includes mountain celery (MC) at 7.5 gkg−1over 42 days. Results Body weight gain and feed conversion ratio significantly (P < 0.05) improved in chicks fed MC. A highly significant down-regulation of genes involved in hepatic lipogenesis including acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), malic enzyme (ME), and lipoprotein lipase (LPL) was observed in the liver of chickens fed MC. These birds, however, had greater compensatory upregulation in antioxidative genes SOD1 and catalase in the liver compared to the birds that received the control diet. Birds received MC had significantly lower level of lipid peroxidation (1.59 μmol/L serum malondialdehyde) compared to birds from the control group (3.57 μmol/L; P = 0.0024). Birds fed MC had significantly (P < 0.05) lower circulatory concentrations of triacylglycerols, cholesterol, and LDL but higher concentrations of HDL. Relative liver weight and abdominal fat deposition were significantly reduced by feeding MC. Conclusions It can be concluded that feeding birds MC significantly suppresses hepatic lipogenesis by down-regulating key hepatic lipogenic enzyme genes and boosts antioxidant capacity by up-regulating hepatic antioxidantive genes.http://link.springer.com/article/10.1186/s12917-018-1561-6AntioxidantChickenCeleryHepatic lipogenesis |
| spellingShingle | Behnam Ahmadipour Hossein Hassanpour Fariborz Khajali Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery BMC Veterinary Research Antioxidant Chicken Celery Hepatic lipogenesis |
| title | Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery |
| title_full | Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery |
| title_fullStr | Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery |
| title_full_unstemmed | Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery |
| title_short | Evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery |
| title_sort | evaluation of hepatic lipogenesis and antioxidant status of broiler chickens fed mountain celery |
| topic | Antioxidant Chicken Celery Hepatic lipogenesis |
| url | http://link.springer.com/article/10.1186/s12917-018-1561-6 |
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