Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results
A single-site, randomized clinical trial was designed to determine the efficacy of regular home use of Lumoral<sup>®</sup> dual-light antibacterial aPDT in periodontitis patients. For the study, 200 patients were randomized to receive non-surgical periodontal treatment (NSPT), including...
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MDPI AG
2022-11-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/10/11/206 |
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| author | Saila Pakarinen Riitta K. T. Saarela Hannamari Välimaa Anna Maria Heikkinen Esko Kankuri Marja Noponen Heikki Alapulli Taina Tervahartiala Ismo T. Räisänen Timo Sorsa Tommi Pätilä |
| author_facet | Saila Pakarinen Riitta K. T. Saarela Hannamari Välimaa Anna Maria Heikkinen Esko Kankuri Marja Noponen Heikki Alapulli Taina Tervahartiala Ismo T. Räisänen Timo Sorsa Tommi Pätilä |
| author_sort | Saila Pakarinen |
| collection | DOAJ |
| description | A single-site, randomized clinical trial was designed to determine the efficacy of regular home use of Lumoral<sup>®</sup> dual-light antibacterial aPDT in periodontitis patients. For the study, 200 patients were randomized to receive non-surgical periodontal treatment (NSPT), including standardized hygiene instructions and electric toothbrush, scaling and root planing, or NSPT with adjunctive Lumoral<sup>®</sup> treatment. A complete clinical intraoral examination was conducted in the beginning, at three months, and at six months. This report presents the three-month results of the first 59 consecutive randomized subjects. At three months, bleeding on probing (BOP) was lower in the NSPT + Lumoral<sup>®</sup>-group than in the NSPT group (<i>p</i> = 0.045), and more patients in the NSPT + Lumoral<sup>®</sup>-group had their BOP below 10% (54% vs. 22%, respectively, <i>p</i> = 0.008). In addition, patients in the NSPT + Lumoral<sup>®</sup>-group improved their oral hygiene by visible-plaque-index (<i>p</i> = 0.0003), while the NSPT group showed no statistical improvement compared to the baseline. Both groups significantly reduced the number of deep periodontal pockets, but more patients with a reduction in their deep pocket number were found in the NSPT + Lumoral<sup>®</sup> group (92% vs. 63%, <i>p</i> = 0.02). Patients whose number of deep pockets was reduced by 50% or more were also more frequent in the NSPT + Lumoral<sup>®</sup>-group (71% vs. 33%, <i>p</i> = 0.01). Patients with initially less than ten deep pockets had fewer deep pockets at the three-month follow-up in the Lumoral<sup>®</sup> group (<i>p</i> = 0.01). In conclusion, adjunctive use of Lumoral<sup>®</sup> in NSPT results in improved treatment outcomes at three months post-therapy. |
| first_indexed | 2024-03-09T19:09:39Z |
| format | Article |
| id | doaj.art-b92b497b9ce044cf8814df71567824c6 |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-09T19:09:39Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-b92b497b9ce044cf8814df71567824c62023-11-24T04:17:11ZengMDPI AGDentistry Journal2304-67672022-11-01101120610.3390/dj10110206Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim ResultsSaila Pakarinen0Riitta K. T. Saarela1Hannamari Välimaa2Anna Maria Heikkinen3Esko Kankuri4Marja Noponen5Heikki Alapulli6Taina Tervahartiala7Ismo T. Räisänen8Timo Sorsa9Tommi Pätilä10Degree Program of Oral Hygiene, Metropolia University of Applied Sciences, 00920 Helsinki, FinlandDepartment of Oral Health, Health and Social Services, 00530 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, FinlandFaculty of Medicine and Health Technology, University of Tampere, 33520 Tampere, FinlandDepartment of Pharmacology, Helsinki University, 00100 Helsinki, FinlandDepartment of Oral Health, Health and Social Services, 00530 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, FinlandDepartment of Congenital Heart Surgery and Organ Transplantation, New Children’s Hospital, University of Helsinki, 00290 Helsinki, FinlandA single-site, randomized clinical trial was designed to determine the efficacy of regular home use of Lumoral<sup>®</sup> dual-light antibacterial aPDT in periodontitis patients. For the study, 200 patients were randomized to receive non-surgical periodontal treatment (NSPT), including standardized hygiene instructions and electric toothbrush, scaling and root planing, or NSPT with adjunctive Lumoral<sup>®</sup> treatment. A complete clinical intraoral examination was conducted in the beginning, at three months, and at six months. This report presents the three-month results of the first 59 consecutive randomized subjects. At three months, bleeding on probing (BOP) was lower in the NSPT + Lumoral<sup>®</sup>-group than in the NSPT group (<i>p</i> = 0.045), and more patients in the NSPT + Lumoral<sup>®</sup>-group had their BOP below 10% (54% vs. 22%, respectively, <i>p</i> = 0.008). In addition, patients in the NSPT + Lumoral<sup>®</sup>-group improved their oral hygiene by visible-plaque-index (<i>p</i> = 0.0003), while the NSPT group showed no statistical improvement compared to the baseline. Both groups significantly reduced the number of deep periodontal pockets, but more patients with a reduction in their deep pocket number were found in the NSPT + Lumoral<sup>®</sup> group (92% vs. 63%, <i>p</i> = 0.02). Patients whose number of deep pockets was reduced by 50% or more were also more frequent in the NSPT + Lumoral<sup>®</sup>-group (71% vs. 33%, <i>p</i> = 0.01). Patients with initially less than ten deep pockets had fewer deep pockets at the three-month follow-up in the Lumoral<sup>®</sup> group (<i>p</i> = 0.01). In conclusion, adjunctive use of Lumoral<sup>®</sup> in NSPT results in improved treatment outcomes at three months post-therapy.https://www.mdpi.com/2304-6767/10/11/206antibacterial photodynamic therapyoral hygieneperiodontitis |
| spellingShingle | Saila Pakarinen Riitta K. T. Saarela Hannamari Välimaa Anna Maria Heikkinen Esko Kankuri Marja Noponen Heikki Alapulli Taina Tervahartiala Ismo T. Räisänen Timo Sorsa Tommi Pätilä Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results Dentistry Journal antibacterial photodynamic therapy oral hygiene periodontitis |
| title | Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results |
| title_full | Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results |
| title_fullStr | Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results |
| title_full_unstemmed | Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results |
| title_short | Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results |
| title_sort | home applied dual light photodynamic therapy in the treatment of stable chronic periodontitis hope cp three month interim results |
| topic | antibacterial photodynamic therapy oral hygiene periodontitis |
| url | https://www.mdpi.com/2304-6767/10/11/206 |
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