The role of C-peptide in diabetes and its complications: an updated review
Worldwide, diabetes and its complications have seriously affected people’s quality of life and become a serious public health problem. C-peptide is not only an indicator of pancreatic β-cell function, but also a biologically active peptide that can bind to cell membrane surface signaling molecules a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1256093/full |
| _version_ | 1797690659116679168 |
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| author | Jintao Chen Yajing Huang Chuanfeng Liu Jingwei Chi Yangang Wang Lili Xu |
| author_facet | Jintao Chen Yajing Huang Chuanfeng Liu Jingwei Chi Yangang Wang Lili Xu |
| author_sort | Jintao Chen |
| collection | DOAJ |
| description | Worldwide, diabetes and its complications have seriously affected people’s quality of life and become a serious public health problem. C-peptide is not only an indicator of pancreatic β-cell function, but also a biologically active peptide that can bind to cell membrane surface signaling molecules and activate downstream signaling pathways to play antioxidant, anti-apoptotic and inflammatory roles, or regulate cellular transcription through internalization. It is complex how C-peptide is related to diabetic complications. Both deficiencies and overproduction can lead to complications, but their mechanisms of action may be different. C-peptide replacement therapy has shown beneficial effects on diabetic complications in animal models when C-peptide is deficient, but results from clinical trials have been unsatisfactory. The complex pattern of the relationship between C-peptide and diabetic chronic complications has not yet been fully understood. Future basic and clinical studies of C-peptide replacement therapies will need to focus on baseline levels of C-peptide in addition to more attention also needs to be paid to post-treatment C-peptide levels to explore the optimal range of fasting C-peptide and postprandial C-peptide maintenance. |
| first_indexed | 2024-03-12T02:02:31Z |
| format | Article |
| id | doaj.art-b92d060cbf3c487c9b9874054e78608a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T02:02:31Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b92d060cbf3c487c9b9874054e78608a2023-09-07T12:16:39ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-09-011410.3389/fendo.2023.12560931256093The role of C-peptide in diabetes and its complications: an updated reviewJintao ChenYajing HuangChuanfeng LiuJingwei ChiYangang WangLili XuWorldwide, diabetes and its complications have seriously affected people’s quality of life and become a serious public health problem. C-peptide is not only an indicator of pancreatic β-cell function, but also a biologically active peptide that can bind to cell membrane surface signaling molecules and activate downstream signaling pathways to play antioxidant, anti-apoptotic and inflammatory roles, or regulate cellular transcription through internalization. It is complex how C-peptide is related to diabetic complications. Both deficiencies and overproduction can lead to complications, but their mechanisms of action may be different. C-peptide replacement therapy has shown beneficial effects on diabetic complications in animal models when C-peptide is deficient, but results from clinical trials have been unsatisfactory. The complex pattern of the relationship between C-peptide and diabetic chronic complications has not yet been fully understood. Future basic and clinical studies of C-peptide replacement therapies will need to focus on baseline levels of C-peptide in addition to more attention also needs to be paid to post-treatment C-peptide levels to explore the optimal range of fasting C-peptide and postprandial C-peptide maintenance.https://www.frontiersin.org/articles/10.3389/fendo.2023.1256093/fullC-peptidediabetic kidney diseasediabetic retinopathydiabetic peripheral neuropathynon-alcoholic fatty liver diseasemacrovascular complications |
| spellingShingle | Jintao Chen Yajing Huang Chuanfeng Liu Jingwei Chi Yangang Wang Lili Xu The role of C-peptide in diabetes and its complications: an updated review Frontiers in Endocrinology C-peptide diabetic kidney disease diabetic retinopathy diabetic peripheral neuropathy non-alcoholic fatty liver disease macrovascular complications |
| title | The role of C-peptide in diabetes and its complications: an updated review |
| title_full | The role of C-peptide in diabetes and its complications: an updated review |
| title_fullStr | The role of C-peptide in diabetes and its complications: an updated review |
| title_full_unstemmed | The role of C-peptide in diabetes and its complications: an updated review |
| title_short | The role of C-peptide in diabetes and its complications: an updated review |
| title_sort | role of c peptide in diabetes and its complications an updated review |
| topic | C-peptide diabetic kidney disease diabetic retinopathy diabetic peripheral neuropathy non-alcoholic fatty liver disease macrovascular complications |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1256093/full |
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