Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis
Background and purposeAnti-titin antibodies are antistriational antibodies associated with thymoma-associated myasthenia gravis (MG). We evaluated whether the patients with anti-titin antibody are more frequently hospitalized to manage thymoma-associated MG than those patients without anti-titin ant...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.978997/full |
| _version_ | 1811199031872847872 |
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| author | Ki Hoon Kim Seung Woo Kim Jinhyuk Cho Hye Yoon Chung Ha Young Shin |
| author_facet | Ki Hoon Kim Seung Woo Kim Jinhyuk Cho Hye Yoon Chung Ha Young Shin |
| author_sort | Ki Hoon Kim |
| collection | DOAJ |
| description | Background and purposeAnti-titin antibodies are antistriational antibodies associated with thymoma-associated myasthenia gravis (MG). We evaluated whether the patients with anti-titin antibody are more frequently hospitalized to manage thymoma-associated MG than those patients without anti-titin antibody.MethodsPatients with thymoma-associated MG who conducted the serological test for anti-titin antibody were retrospectively included. Disease severity, treatments, MG-related annual hospitalization rate, and MG-related emergency room (ER) visit rate were compared between the patients with anti-titin antibody and those patients without anti-titin antibody. Multivariate analysis was conducted to analyze the association between anti-titin antibody serostatus and multiple admissions (hospitalization or ER visit of ≥2 times).ResultsOf the 64 included patients, 31 (48.4%) patients were positive for anti-titin antibody (titin+ group) and 33 (51.6%) patients were negative for anti-titin antibody (titin– group). Both the annual rate of MG-related hospitalization and ER visit were significantly higher in the titin+ group [0.2 (0.1–0.6) and 0.1 (0–0.2) per year, respectively] than those in the titin– group [0 (0–0.2) and 0 (0–0) per year, p = 0.004 and p = 0.006, respectively]. In multivariate analysis, positive anti-titin antibody was still significantly associated with multiple admissions [odds ratio (OR) 4.11, 95% CI 1.05–16.03] compared to the titin– group as a reference after adjusting for sex, follow-up duration, age at onset, systemic chemotherapy, and the Masaoka staging.ConclusionThe presence of anti-titin antibody is associated with more frequent hospital utilization. Personalized explanation and careful monitoring strategy could be required in patients with thymoma-associated MG with anti-titin antibody for the timely detection of relapses. |
| first_indexed | 2024-04-12T01:41:03Z |
| format | Article |
| id | doaj.art-b92dbba9c98743aba8527c76b703d99f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T01:41:03Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-b92dbba9c98743aba8527c76b703d99f2022-12-22T03:53:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-10-011310.3389/fneur.2022.978997978997Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravisKi Hoon Kim0Seung Woo Kim1Jinhyuk Cho2Hye Yoon Chung3Ha Young Shin4Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, South KoreaYonsei University College of Medicine, Seoul, South KoreaYonsei University College of Medicine, Seoul, South KoreaYonsei University College of Medicine, Seoul, South KoreaYonsei University College of Medicine, Seoul, South KoreaBackground and purposeAnti-titin antibodies are antistriational antibodies associated with thymoma-associated myasthenia gravis (MG). We evaluated whether the patients with anti-titin antibody are more frequently hospitalized to manage thymoma-associated MG than those patients without anti-titin antibody.MethodsPatients with thymoma-associated MG who conducted the serological test for anti-titin antibody were retrospectively included. Disease severity, treatments, MG-related annual hospitalization rate, and MG-related emergency room (ER) visit rate were compared between the patients with anti-titin antibody and those patients without anti-titin antibody. Multivariate analysis was conducted to analyze the association between anti-titin antibody serostatus and multiple admissions (hospitalization or ER visit of ≥2 times).ResultsOf the 64 included patients, 31 (48.4%) patients were positive for anti-titin antibody (titin+ group) and 33 (51.6%) patients were negative for anti-titin antibody (titin– group). Both the annual rate of MG-related hospitalization and ER visit were significantly higher in the titin+ group [0.2 (0.1–0.6) and 0.1 (0–0.2) per year, respectively] than those in the titin– group [0 (0–0.2) and 0 (0–0) per year, p = 0.004 and p = 0.006, respectively]. In multivariate analysis, positive anti-titin antibody was still significantly associated with multiple admissions [odds ratio (OR) 4.11, 95% CI 1.05–16.03] compared to the titin– group as a reference after adjusting for sex, follow-up duration, age at onset, systemic chemotherapy, and the Masaoka staging.ConclusionThe presence of anti-titin antibody is associated with more frequent hospital utilization. Personalized explanation and careful monitoring strategy could be required in patients with thymoma-associated MG with anti-titin antibody for the timely detection of relapses.https://www.frontiersin.org/articles/10.3389/fneur.2022.978997/fullanti-titin antibodymyasthenia gravisannual admission ratethymomadisease activity |
| spellingShingle | Ki Hoon Kim Seung Woo Kim Jinhyuk Cho Hye Yoon Chung Ha Young Shin Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis Frontiers in Neurology anti-titin antibody myasthenia gravis annual admission rate thymoma disease activity |
| title | Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis |
| title_full | Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis |
| title_fullStr | Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis |
| title_full_unstemmed | Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis |
| title_short | Anti-titin antibody is associated with more frequent hospitalization to manage thymoma-associated myasthenia gravis |
| title_sort | anti titin antibody is associated with more frequent hospitalization to manage thymoma associated myasthenia gravis |
| topic | anti-titin antibody myasthenia gravis annual admission rate thymoma disease activity |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.978997/full |
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