Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease
The increasing prevalence of obesity is a worldwide health concern. Although obesity primarily affects the development of cardiometabolic disorders, it has also been closely linked to chronic kidney disease (CKD). However, potential causal relationships between obesity and CKD remain unclear, as obe...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society for the Study of Obesity
2022-09-01
|
| Series: | Journal of Obesity & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.7570/jomes22036 |
| _version_ | 1811180816054616064 |
|---|---|
| author | Yun Kyung Cho Chang Hee Jung |
| author_facet | Yun Kyung Cho Chang Hee Jung |
| author_sort | Yun Kyung Cho |
| collection | DOAJ |
| description | The increasing prevalence of obesity is a worldwide health concern. Although obesity primarily affects the development of cardiometabolic disorders, it has also been closely linked to chronic kidney disease (CKD). However, potential causal relationships between obesity and CKD remain unclear, as obesity and CKD share a number of common risk factors. Accordingly, the risk of incident CKD in obese people without metabolic abnormalities, also called "metabolically healthy obesity" (MHO), has been a matter of interest. Recent investigations found that MHO was related to increased risk of incident CKD; however, the conclusions were based primarily on the static state. According to previous publications, approximately one-half of people initially identified as MHO became metabolically unhealthy, while one-tenth reduced their body weight to normal range while remaining metabolically healthy. It is essential to consider these transitions in obese-metabolic health status when analyzing obesity-related outcomes. This review discusses research on obesity and metabolic health in patients with CKD. Furthermore, we summarize recent reports on the implications of obesity and metabolic health in CKD and discuss the possible mechanisms of their relationship with CKD. |
| first_indexed | 2024-04-11T09:09:45Z |
| format | Article |
| id | doaj.art-b92e0008d77c43cc819b624feb867b2c |
| institution | Directory Open Access Journal |
| issn | 2508-6235 |
| language | English |
| last_indexed | 2024-04-11T09:09:45Z |
| publishDate | 2022-09-01 |
| publisher | Korean Society for the Study of Obesity |
| record_format | Article |
| series | Journal of Obesity & Metabolic Syndrome |
| spelling | doaj.art-b92e0008d77c43cc819b624feb867b2c2022-12-22T04:32:32ZengKorean Society for the Study of ObesityJournal of Obesity & Metabolic Syndrome2508-62352022-09-0131320821610.7570/jomes22036jomes22036Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney DiseaseYun Kyung Cho0Chang Hee Jung1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaThe increasing prevalence of obesity is a worldwide health concern. Although obesity primarily affects the development of cardiometabolic disorders, it has also been closely linked to chronic kidney disease (CKD). However, potential causal relationships between obesity and CKD remain unclear, as obesity and CKD share a number of common risk factors. Accordingly, the risk of incident CKD in obese people without metabolic abnormalities, also called "metabolically healthy obesity" (MHO), has been a matter of interest. Recent investigations found that MHO was related to increased risk of incident CKD; however, the conclusions were based primarily on the static state. According to previous publications, approximately one-half of people initially identified as MHO became metabolically unhealthy, while one-tenth reduced their body weight to normal range while remaining metabolically healthy. It is essential to consider these transitions in obese-metabolic health status when analyzing obesity-related outcomes. This review discusses research on obesity and metabolic health in patients with CKD. Furthermore, we summarize recent reports on the implications of obesity and metabolic health in CKD and discuss the possible mechanisms of their relationship with CKD.http://journaleditor.inforang.com/journal/view.html?doi=10.7570/jomes22036chronic kidney diseasemetabolic syndromeobesity |
| spellingShingle | Yun Kyung Cho Chang Hee Jung Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease Journal of Obesity & Metabolic Syndrome chronic kidney disease metabolic syndrome obesity |
| title | Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease |
| title_full | Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease |
| title_fullStr | Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease |
| title_full_unstemmed | Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease |
| title_short | Metabolically Healthy Obesity: Epidemiology, Criteria, and Implications in Chronic Kidney Disease |
| title_sort | metabolically healthy obesity epidemiology criteria and implications in chronic kidney disease |
| topic | chronic kidney disease metabolic syndrome obesity |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.7570/jomes22036 |
| work_keys_str_mv | AT yunkyungcho metabolicallyhealthyobesityepidemiologycriteriaandimplicationsinchronickidneydisease AT changheejung metabolicallyhealthyobesityepidemiologycriteriaandimplicationsinchronickidneydisease |