Microglia–Astrocyte Communication via C1q Contributes to Orofacial Neuropathic Pain Associated with Infraorbital Nerve Injury

Microglia–Astrocyte Communication via C1q Contributes to Orofacial Neuropathic Pain Associated with Infraorbital Nerve Injury

Trigeminal nerve injury causes a distinct time window of glial activation in the trigeminal spinal subnucleus caudalis (Vc), which are involved in the initiation and maintenance phases of orofacial neuropathic pain. Microglia-derived factors enable the activation of astrocytes. The complement compon...

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Bibliographic Details
Main Authors: Sayaka Asano, Yoshinori Hayashi, Koichi Iwata, Akiko Okada-Ogawa, Suzuro Hitomi, Ikuko Shibuta, Yoshiki Imamura, Masamichi Shinoda
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
microglia
astrocyte
C1q
infraorbital nerve injury
mechanical hypersensitivity
Online Access:https://www.mdpi.com/1422-0067/21/18/6834

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