A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

A rapid, sensitive, and robust reversed-phase liquid chromatography with tandem mass spectrometry method was developed and validated for the determination of total and unbound ceritinib, a second-generation ALK inhibitor, in patient plasma and brain tumor tissue samples. Sample preparation involved...

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Bibliographic Details
Main Authors:	Xun Bao, Jianmei Wu, Nader Sanai, Jing Li
Format:	Article
Language:	English
Published:	Elsevier 2018-02-01
Series:	Journal of Pharmaceutical Analysis
Subjects:	Ceritinib Reversed-phase liquid chromatography with tandem mass spectrometry (LC–MS/MS) Fraction unbound in plasma Fraction unbound in brain tissue Brain tumor penetration Unbound brain-to-plasma partition coefficient
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177917300953

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