Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE) in military service members: a prospective, observational study protocol
Abstract Background Non-battle related musculoskeletal injuries (MSKI) are one of the primary medical issues diminishing Service member medical readiness. The MSKI problem is challenging because it is difficult to assess all of the factors that increase MSKI risk and influence post-MSKI outcomes. Cu...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03832-7 |
| _version_ | 1797977290738499584 |
|---|---|
| author | Courtney M. Butowicz Brad D. Hendershot Nora L. Watson Daniel I. Brooks Donald L. Goss Robert A. Whitehurst Alisha D. Harvey Matthew S. Helton Joseph R. Kardouni Matthew B. Garber Timothy C. Mauntel |
| author_facet | Courtney M. Butowicz Brad D. Hendershot Nora L. Watson Daniel I. Brooks Donald L. Goss Robert A. Whitehurst Alisha D. Harvey Matthew S. Helton Joseph R. Kardouni Matthew B. Garber Timothy C. Mauntel |
| author_sort | Courtney M. Butowicz |
| collection | DOAJ |
| description | Abstract Background Non-battle related musculoskeletal injuries (MSKI) are one of the primary medical issues diminishing Service member medical readiness. The MSKI problem is challenging because it is difficult to assess all of the factors that increase MSKI risk and influence post-MSKI outcomes. Currently, there are no high-throughput, clinically-feasible, and comprehensive assessments to generate patient-centric data for informing pre- and post-MSKI risk assessment and mitigation strategies. The objective of the “Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE)” study is to develop a comprehensive suite of clinical assessments to identify the patient-specific factors contributing to MSKI risks and undesired post-MSKI outcomes. Methods This is a phased approach, multi-center prospective, observational study (ClinicalTrials.gov number: NCT05111925) to identify physical and psychosocial factors contributing to greater MSKI risk and undesired post-MSKI outcomes, and to identify and validate a minimal set of assessments to personalize risk mitigation and rehabilitation strategies. In Phase I, one cohort (n = 560) will identify the physical and psychosocial factors contributing to greater MSKI risks (single assessment), while a second cohort (n = 780) will identify the post-MSKI physical and psychosocial factors contributing to undesired post-MSKI outcomes (serial assessments at enrollment, 4 weeks post-enrollment, 12 weeks post-enrollment). All participants will complete comprehensive movement assessments captured via a semi-automated markerless motion capture system and instrumented walkway, joint range of motion assessments, psychosocial measures, and self-reported physical fitness performance and MSKI history. We will follow participants for 6 months. We will identify the minimum set of clinical assessments that provide requisite data to personalize MSKI risk mitigation and rehabilitation strategies, and in Phase II validate our optimized assessments in new cohorts. Discussion The results of this investigation will provide clinically relevant data to efficiently inform MSKI risk mitigation and rehabilitation programs, thereby helping to advance medical care and retain Service members on active duty status. Trial Registration: PREPARE was prospectively registered on ClinicalTrials.gov (NCT05111925) on 5 NOV 2021, prior to study commencement. |
| first_indexed | 2024-04-11T05:04:31Z |
| format | Article |
| id | doaj.art-b932bb4951dd4c16ae50a17a78255ffc |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-11T05:04:31Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-b932bb4951dd4c16ae50a17a78255ffc2022-12-25T12:27:33ZengBMCJournal of Translational Medicine1479-58762022-12-0120111210.1186/s12967-022-03832-7Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE) in military service members: a prospective, observational study protocolCourtney M. Butowicz0Brad D. Hendershot1Nora L. Watson2Daniel I. Brooks3Donald L. Goss4Robert A. Whitehurst5Alisha D. Harvey6Matthew S. Helton7Joseph R. Kardouni8Matthew B. Garber9Timothy C. Mauntel10Research & Surveillance Division, Extremity Trauma and Amputation Center of ExcellenceResearch & Surveillance Division, Extremity Trauma and Amputation Center of ExcellenceDepartment of Research, Walter Reed National Military Medical CenterClinical Quality Management, Defense Health AgencyDepartment of Physical Therapy, High Point UniversityU.S. Army Forces CommandPhysical Therapy Service, Department of Rehabilitation, Walter Reed National Military Medical CenterU.S. Army Forces CommandU.S. Army Forces CommandDepartment of Health, Human Function and Rehabilitation Science, The George Washington UniversityResearch & Surveillance Divsion, Extremity Trauma & Amputation Center of ExcellenceAbstract Background Non-battle related musculoskeletal injuries (MSKI) are one of the primary medical issues diminishing Service member medical readiness. The MSKI problem is challenging because it is difficult to assess all of the factors that increase MSKI risk and influence post-MSKI outcomes. Currently, there are no high-throughput, clinically-feasible, and comprehensive assessments to generate patient-centric data for informing pre- and post-MSKI risk assessment and mitigation strategies. The objective of the “Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE)” study is to develop a comprehensive suite of clinical assessments to identify the patient-specific factors contributing to MSKI risks and undesired post-MSKI outcomes. Methods This is a phased approach, multi-center prospective, observational study (ClinicalTrials.gov number: NCT05111925) to identify physical and psychosocial factors contributing to greater MSKI risk and undesired post-MSKI outcomes, and to identify and validate a minimal set of assessments to personalize risk mitigation and rehabilitation strategies. In Phase I, one cohort (n = 560) will identify the physical and psychosocial factors contributing to greater MSKI risks (single assessment), while a second cohort (n = 780) will identify the post-MSKI physical and psychosocial factors contributing to undesired post-MSKI outcomes (serial assessments at enrollment, 4 weeks post-enrollment, 12 weeks post-enrollment). All participants will complete comprehensive movement assessments captured via a semi-automated markerless motion capture system and instrumented walkway, joint range of motion assessments, psychosocial measures, and self-reported physical fitness performance and MSKI history. We will follow participants for 6 months. We will identify the minimum set of clinical assessments that provide requisite data to personalize MSKI risk mitigation and rehabilitation strategies, and in Phase II validate our optimized assessments in new cohorts. Discussion The results of this investigation will provide clinically relevant data to efficiently inform MSKI risk mitigation and rehabilitation programs, thereby helping to advance medical care and retain Service members on active duty status. Trial Registration: PREPARE was prospectively registered on ClinicalTrials.gov (NCT05111925) on 5 NOV 2021, prior to study commencement.https://doi.org/10.1186/s12967-022-03832-7Musculoskeletal injuryNeuromuscularMilitaryService memberTactical athleteRisk assessment |
| spellingShingle | Courtney M. Butowicz Brad D. Hendershot Nora L. Watson Daniel I. Brooks Donald L. Goss Robert A. Whitehurst Alisha D. Harvey Matthew S. Helton Joseph R. Kardouni Matthew B. Garber Timothy C. Mauntel Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE) in military service members: a prospective, observational study protocol Journal of Translational Medicine Musculoskeletal injury Neuromuscular Military Service member Tactical athlete Risk assessment |
| title | Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE) in military service members: a prospective, observational study protocol |
| title_full | Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE) in military service members: a prospective, observational study protocol |
| title_fullStr | Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE) in military service members: a prospective, observational study protocol |
| title_full_unstemmed | Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE) in military service members: a prospective, observational study protocol |
| title_short | Pre-neuromusculoskeletal injury Risk factor Evaluation and Post-neuromusculoskeletal injury Assessment for Return-to-duty/activity Enhancement (PREPARE) in military service members: a prospective, observational study protocol |
| title_sort | pre neuromusculoskeletal injury risk factor evaluation and post neuromusculoskeletal injury assessment for return to duty activity enhancement prepare in military service members a prospective observational study protocol |
| topic | Musculoskeletal injury Neuromuscular Military Service member Tactical athlete Risk assessment |
| url | https://doi.org/10.1186/s12967-022-03832-7 |
| work_keys_str_mv | AT courtneymbutowicz preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT braddhendershot preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT noralwatson preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT danielibrooks preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT donaldlgoss preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT robertawhitehurst preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT alishadharvey preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT matthewshelton preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT josephrkardouni preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT matthewbgarber preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol AT timothycmauntel preneuromusculoskeletalinjuryriskfactorevaluationandpostneuromusculoskeletalinjuryassessmentforreturntodutyactivityenhancementprepareinmilitaryservicemembersaprospectiveobservationalstudyprotocol |