A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis
Objectives: To test the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental state for psychosis. Methods: Through general population screening, 88 non-help-seeking UHR subjects and 130 healthy c...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2023-07-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462023000300268&lng=en&tlng=en |
| _version_ | 1797788070399967232 |
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| author | Julia Hatagami Marques Leda Leme Talib Lucas Hortêncio Julio Cesar Andrade Tania Maria Alves Mauricio Henriques Serpa Guilherme Lopes Yamamoto Martinus Theodorus van de Bilt Wulf Rössler Wagner Farid Gattaz Alexandre Andrade Loch |
| author_facet | Julia Hatagami Marques Leda Leme Talib Lucas Hortêncio Julio Cesar Andrade Tania Maria Alves Mauricio Henriques Serpa Guilherme Lopes Yamamoto Martinus Theodorus van de Bilt Wulf Rössler Wagner Farid Gattaz Alexandre Andrade Loch |
| author_sort | Julia Hatagami Marques |
| collection | DOAJ |
| description | Objectives: To test the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental state for psychosis. Methods: Through general population screening, 88 non-help-seeking UHR subjects and 130 healthy control individuals were genotyped for 45 SNPs related to psychosis. They were followed for a mean of 2.5 years, and conversion to psychotic and to general psychiatric disorders was assessed. Genotype frequencies between controls, converters, and non-converters were analyzed. Results: There were no differences in sociodemographics between controls and UHR. Also, UHR converters and non-converters had no differences in their baseline symptoms scores. The dopamine receptor D2 gene (DRD2) SNP rs6277 was significantly more common among UHR who transitioned to psychosis (p < 0.001) and to UHR who transitioned to any psychiatric disorders (p = 0.001) when compared to UHR who did not transition. The rs6277 T allele was related to psychiatric morbidity in a dose-response fashion, being significantly more frequent in UHR converters than UHR non-converters and control subjects (p = 0.003). Conclusion: Our findings suggest that rs6277 could potentially constitute a genetic marker of transition to psychiatric disorders in subjects with at-risk mental states, warranting further investigation in larger samples. |
| first_indexed | 2024-03-13T01:31:18Z |
| format | Article |
| id | doaj.art-b9332a119bce463c9f1ca786632f418f |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-03-13T01:31:18Z |
| publishDate | 2023-07-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-b9332a119bce463c9f1ca786632f418f2023-07-04T07:45:53ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2023-07-0145326827310.47626/1516-4446-2023-3044A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosisJulia Hatagami MarquesLeda Leme Talibhttps://orcid.org/0000-0001-5866-1993Lucas Hortênciohttps://orcid.org/0000-0001-5572-6093Julio Cesar AndradeTania Maria AlvesMauricio Henriques SerpaGuilherme Lopes YamamotoMartinus Theodorus van de BiltWulf RösslerWagner Farid GattazAlexandre Andrade Lochhttps://orcid.org/0000-0002-0006-8107 Objectives: To test the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental state for psychosis. Methods: Through general population screening, 88 non-help-seeking UHR subjects and 130 healthy control individuals were genotyped for 45 SNPs related to psychosis. They were followed for a mean of 2.5 years, and conversion to psychotic and to general psychiatric disorders was assessed. Genotype frequencies between controls, converters, and non-converters were analyzed. Results: There were no differences in sociodemographics between controls and UHR. Also, UHR converters and non-converters had no differences in their baseline symptoms scores. The dopamine receptor D2 gene (DRD2) SNP rs6277 was significantly more common among UHR who transitioned to psychosis (p < 0.001) and to UHR who transitioned to any psychiatric disorders (p = 0.001) when compared to UHR who did not transition. The rs6277 T allele was related to psychiatric morbidity in a dose-response fashion, being significantly more frequent in UHR converters than UHR non-converters and control subjects (p = 0.003). Conclusion: Our findings suggest that rs6277 could potentially constitute a genetic marker of transition to psychiatric disorders in subjects with at-risk mental states, warranting further investigation in larger samples.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462023000300268&lng=en&tlng=enDopamineschizophreniaclinical high riskflip-flopattenuated psychosis |
| spellingShingle | Julia Hatagami Marques Leda Leme Talib Lucas Hortêncio Julio Cesar Andrade Tania Maria Alves Mauricio Henriques Serpa Guilherme Lopes Yamamoto Martinus Theodorus van de Bilt Wulf Rössler Wagner Farid Gattaz Alexandre Andrade Loch A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis Brazilian Journal of Psychiatry Dopamine schizophrenia clinical high risk flip-flop attenuated psychosis |
| title | A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis |
| title_full | A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis |
| title_fullStr | A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis |
| title_full_unstemmed | A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis |
| title_short | A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis |
| title_sort | dopamine receptor d2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at risk mental state for psychosis |
| topic | Dopamine schizophrenia clinical high risk flip-flop attenuated psychosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462023000300268&lng=en&tlng=en |
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