Development and Validation of a Bioanalytical LC-MS/MS Method for Simultaneous Determination of Sirolimus in Porcine Whole Blood and Lung Tissue and Pharmacokinetic Application with Coronary Stents

Development and Validation of a Bioanalytical LC-MS/MS Method for Simultaneous Determination of Sirolimus in Porcine Whole Blood and Lung Tissue and Pharmacokinetic Application with Coronary Stents

Sirolimus is a hydrophobic macrolide compound that has been used for long-term immunosuppressive therapy, prevention of restenosis, and treatment of lymphangioleiomyomatosis. In this study, a simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated f...

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Bibliographic Details
Main Authors: Thi-Thao-Linh Nguyen, Van-An Duong, Dang-Khoa Vo, Jeongae Jo, Han-Joo Maeng
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
sirolimus
LC-MS/MS
validation
whole blood
lung tissue
pharmacokinetic
Online Access:https://www.mdpi.com/1420-3049/26/2/425

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