Socs1-knockout in skin-resident CD4+ T cells in a protracted contact-allergic reaction results in an autonomous skin inflammation with features of early-stage mycosis fungoides

Socs1-knockout in skin-resident CD4+ T cells in a protracted contact-allergic reaction results in an autonomous skin inflammation with features of early-stage mycosis fungoides

Recent detailed genomic analysis of mycosis fungoides (MF) identified suppressor of cytokine signaling 1 (SOCS1), an inhibitor of JAK/STAT signaling, as one of the frequently deleted tumor suppressors in MF, and one-copy deletion of SOCS1 was confirmed in early-stage MF lesions. To better understand...

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Bibliographic Details
Main Authors: Yixin Luo, Maarten H. Vermeer, Sanne de Haan, Priscilla Kinderman, Frank R. de Gruijl, Thorbald van Hall, Cornelis P. Tensen
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Mycosis fungoides
CD4+ T cells
Inflammation
Transgenic mouse
Socs1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823001164

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