<i>Helicobacter pylori</i> BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development
<i>Helicobacter pylori</i> is a pathogenic microorganism that successfully inhabits the human stomach, colonizing it by producing several virulence factors responsible for preventing host self-defense mechanisms. The adherence mechanism to gastric mucosal tissue is one of the most import...
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MDPI AG
2021-07-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/7/485 |
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| author | Dalla Doohan Yudith Annisa Ayu Rezkitha Langgeng Agung Waskito Yoshio Yamaoka Muhammad Miftahussurur |
| author_facet | Dalla Doohan Yudith Annisa Ayu Rezkitha Langgeng Agung Waskito Yoshio Yamaoka Muhammad Miftahussurur |
| author_sort | Dalla Doohan |
| collection | DOAJ |
| description | <i>Helicobacter pylori</i> is a pathogenic microorganism that successfully inhabits the human stomach, colonizing it by producing several virulence factors responsible for preventing host self-defense mechanisms. The adherence mechanism to gastric mucosal tissue is one of the most important processes for effective colonization in the stomach. The blood group antigen-binding adhesion (BabA) and sialic acid-binding adherence (SabA) are two <i>H. pylori</i> outer membrane proteins able to interact with antigens in the gastroduodenal tract. <i>H. pylori</i> possesses several mechanisms to control the regulation of both BabA and SabA in either the transcriptional or translational level. BabA is believed to be the most important protein in the early infection phase due to its ability to interact with various Lewis antigens, whereas SabA interaction with sialylated Lewis antigens may prove important for the adherence process in the inflamed gastric mucosal tissue in the ongoing-infection phase. The adherence mechanisms of BabA and SabA allow <i>H. pylori</i> to anchor in the gastric mucosa and begin the colonization process. |
| first_indexed | 2024-03-10T09:21:04Z |
| format | Article |
| id | doaj.art-b9357d933957485e95cea7e66ab2752b |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T09:21:04Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-b9357d933957485e95cea7e66ab2752b2023-11-22T05:11:00ZengMDPI AGToxins2072-66512021-07-0113748510.3390/toxins13070485<i>Helicobacter pylori</i> BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease DevelopmentDalla Doohan0Yudith Annisa Ayu Rezkitha1Langgeng Agung Waskito2Yoshio Yamaoka3Muhammad Miftahussurur4Faculty of Medicine, Universitas Airlangga, Surabaya 60131, IndonesiaFaculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya 60113, IndonesiaFaculty of Medicine, Universitas Airlangga, Surabaya 60131, IndonesiaDepartment of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, JapanDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine—Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia<i>Helicobacter pylori</i> is a pathogenic microorganism that successfully inhabits the human stomach, colonizing it by producing several virulence factors responsible for preventing host self-defense mechanisms. The adherence mechanism to gastric mucosal tissue is one of the most important processes for effective colonization in the stomach. The blood group antigen-binding adhesion (BabA) and sialic acid-binding adherence (SabA) are two <i>H. pylori</i> outer membrane proteins able to interact with antigens in the gastroduodenal tract. <i>H. pylori</i> possesses several mechanisms to control the regulation of both BabA and SabA in either the transcriptional or translational level. BabA is believed to be the most important protein in the early infection phase due to its ability to interact with various Lewis antigens, whereas SabA interaction with sialylated Lewis antigens may prove important for the adherence process in the inflamed gastric mucosal tissue in the ongoing-infection phase. The adherence mechanisms of BabA and SabA allow <i>H. pylori</i> to anchor in the gastric mucosa and begin the colonization process.https://www.mdpi.com/2072-6651/13/7/485BabASabAadherenceinfectious disease |
| spellingShingle | Dalla Doohan Yudith Annisa Ayu Rezkitha Langgeng Agung Waskito Yoshio Yamaoka Muhammad Miftahussurur <i>Helicobacter pylori</i> BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development Toxins BabA SabA adherence infectious disease |
| title | <i>Helicobacter pylori</i> BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development |
| title_full | <i>Helicobacter pylori</i> BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development |
| title_fullStr | <i>Helicobacter pylori</i> BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development |
| title_full_unstemmed | <i>Helicobacter pylori</i> BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development |
| title_short | <i>Helicobacter pylori</i> BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development |
| title_sort | i helicobacter pylori i baba saba key roles in the adherence phase the synergic mechanism for successful colonization and disease development |
| topic | BabA SabA adherence infectious disease |
| url | https://www.mdpi.com/2072-6651/13/7/485 |
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