The mediating role of negative symptoms in “secondary factors” determining social functioning in chronic schizophrenia
BackgroundChronic schizophrenia is significantly influenced by negative symptoms, with several known contributors to secondary negative symptoms. However, the impact of these factors and negative symptoms on social functioning warrants further exploration.MethodsWe assessed the clinical symptoms, an...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1196760/full |
| _version_ | 1797742341038014464 |
|---|---|
| author | Na Hu Wei Li Hu Deng Jiaqi Song Hanxue Yang Jiabao Chai Wenqian Huang Hong Wang Xuanzi Zhou Pan Zhang Sushuang He Yonghua Cui Tengteng Fan Ying Li |
| author_facet | Na Hu Wei Li Hu Deng Jiaqi Song Hanxue Yang Jiabao Chai Wenqian Huang Hong Wang Xuanzi Zhou Pan Zhang Sushuang He Yonghua Cui Tengteng Fan Ying Li |
| author_sort | Na Hu |
| collection | DOAJ |
| description | BackgroundChronic schizophrenia is significantly influenced by negative symptoms, with several known contributors to secondary negative symptoms. However, the impact of these factors and negative symptoms on social functioning warrants further exploration.MethodsWe assessed the clinical symptoms, antipsychotic adverse reactions, and social functioning of 283 hospitalized patients with chronic schizophrenia using various standardized interviews and scales. We conducted multiple regression and mediation analyses to elucidate the impact of secondary factors on negative symptoms, and the relationship among these “secondary factors,” negative symptoms, and social functioning.ResultsOur findings identified depressive symptoms, extrapyramidal symptoms, and positive symptoms as significant contributors to secondary negative symptoms. We found that negative symptoms play a notable mediating role in the effect of depressive and positive symptoms on social functioning. However, the relationship between positive symptoms, negative symptoms, and social functioning proved to be intricate.ConclusionOur findings propose that negative symptoms act as pivotal mediators in the correlation between “secondary factors” (including the depressive symptoms and positive symptoms) and social functioning. The treatment of chronic schizophrenia necessitates focusing on key factors such as depressive and positive symptoms, which might significantly contribute to the development of secondary negative symptoms. Further research is essential to clarify the complex relationship among positive symptoms, negative symptoms, and social functioning in schizophrenia. |
| first_indexed | 2024-03-12T14:40:24Z |
| format | Article |
| id | doaj.art-b9358db3baa040b6bacb66f7958f681d |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-12T14:40:24Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-b9358db3baa040b6bacb66f7958f681d2023-08-16T11:48:53ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-08-011410.3389/fpsyt.2023.11967601196760The mediating role of negative symptoms in “secondary factors” determining social functioning in chronic schizophreniaNa Hu0Wei Li1Hu Deng2Jiaqi Song3Hanxue Yang4Jiabao Chai5Wenqian Huang6Hong Wang7Xuanzi Zhou8Pan Zhang9Sushuang He10Yonghua Cui11Tengteng Fan12Ying Li13Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, ChinaBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, ChinaBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, ChinaBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, ChinaSchool of Psychology, Beijing Language and Culture University, Beijing, ChinaBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, ChinaBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, ChinaBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, ChinaFengtai Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Psychology, Hebei Normal University, Shijiazhuang, ChinaBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, ChinaDepartment of Psychiatry, Beijing Children’s Hospital, Capital Medical University, National Center for Children Healthy, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health Peking University, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaDepartment of Psychiatry, Beijing Children’s Hospital, Capital Medical University, National Center for Children Healthy, Beijing, ChinaBackgroundChronic schizophrenia is significantly influenced by negative symptoms, with several known contributors to secondary negative symptoms. However, the impact of these factors and negative symptoms on social functioning warrants further exploration.MethodsWe assessed the clinical symptoms, antipsychotic adverse reactions, and social functioning of 283 hospitalized patients with chronic schizophrenia using various standardized interviews and scales. We conducted multiple regression and mediation analyses to elucidate the impact of secondary factors on negative symptoms, and the relationship among these “secondary factors,” negative symptoms, and social functioning.ResultsOur findings identified depressive symptoms, extrapyramidal symptoms, and positive symptoms as significant contributors to secondary negative symptoms. We found that negative symptoms play a notable mediating role in the effect of depressive and positive symptoms on social functioning. However, the relationship between positive symptoms, negative symptoms, and social functioning proved to be intricate.ConclusionOur findings propose that negative symptoms act as pivotal mediators in the correlation between “secondary factors” (including the depressive symptoms and positive symptoms) and social functioning. The treatment of chronic schizophrenia necessitates focusing on key factors such as depressive and positive symptoms, which might significantly contribute to the development of secondary negative symptoms. Further research is essential to clarify the complex relationship among positive symptoms, negative symptoms, and social functioning in schizophrenia.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1196760/fullsecondary negative symptomschronic schizophreniadepressionpositive symptomssocial functioning |
| spellingShingle | Na Hu Wei Li Hu Deng Jiaqi Song Hanxue Yang Jiabao Chai Wenqian Huang Hong Wang Xuanzi Zhou Pan Zhang Sushuang He Yonghua Cui Tengteng Fan Ying Li The mediating role of negative symptoms in “secondary factors” determining social functioning in chronic schizophrenia Frontiers in Psychiatry secondary negative symptoms chronic schizophrenia depression positive symptoms social functioning |
| title | The mediating role of negative symptoms in “secondary factors” determining social functioning in chronic schizophrenia |
| title_full | The mediating role of negative symptoms in “secondary factors” determining social functioning in chronic schizophrenia |
| title_fullStr | The mediating role of negative symptoms in “secondary factors” determining social functioning in chronic schizophrenia |
| title_full_unstemmed | The mediating role of negative symptoms in “secondary factors” determining social functioning in chronic schizophrenia |
| title_short | The mediating role of negative symptoms in “secondary factors” determining social functioning in chronic schizophrenia |
| title_sort | mediating role of negative symptoms in secondary factors determining social functioning in chronic schizophrenia |
| topic | secondary negative symptoms chronic schizophrenia depression positive symptoms social functioning |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1196760/full |
| work_keys_str_mv | AT nahu themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT weili themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT hudeng themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT jiaqisong themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT hanxueyang themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT jiabaochai themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT wenqianhuang themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT hongwang themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT xuanzizhou themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT panzhang themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT sushuanghe themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT yonghuacui themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT tengtengfan themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT yingli themediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT nahu mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT weili mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT hudeng mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT jiaqisong mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT hanxueyang mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT jiabaochai mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT wenqianhuang mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT hongwang mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT xuanzizhou mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT panzhang mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT sushuanghe mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT yonghuacui mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT tengtengfan mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia AT yingli mediatingroleofnegativesymptomsinsecondaryfactorsdeterminingsocialfunctioninginchronicschizophrenia |