Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trial
Abstract Background Pain and clicking are the primary complaints in patients suffering from temporomandibular joint disc displacement with reduction (DDwR), negatively affecting the patients' quality of life, making the treatment essential. This prospective randomized controlled trial (RCT) was...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-022-02579-3 |
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| author | Nermeen A. Rady Mariam M. Bahgat Ahmed M. Abdel-Hamid |
| author_facet | Nermeen A. Rady Mariam M. Bahgat Ahmed M. Abdel-Hamid |
| author_sort | Nermeen A. Rady |
| collection | DOAJ |
| description | Abstract Background Pain and clicking are the primary complaints in patients suffering from temporomandibular joint disc displacement with reduction (DDwR), negatively affecting the patients' quality of life, making the treatment essential. This prospective randomized controlled trial (RCT) was conducted to evaluate the effectiveness of botulinum toxin type-A (BTX-A) and low level laser therapy (LLLT) in comparison to anterior repositioning appliance (ARA) for the treatment of DDwR. Methods A total of 27 patients were randomly allocated to 3 groups; ARA (control group), BTX-A, and LLLT; with 9 patients each. All patients were evaluated before and 3 months after the treatment using a visual analogue scale (VAS) and magnetic resonance imaging (MRI). Results At 3 months follow-up, all groups showed a significant reduction in pain assessed by VAS (P = 0.007). Measured on MRI, there was a significant improvement in disc position and joint space index (JSI) in BTX-A group (P < 0.001, P = 0.011) and LLLT group (P = 0.002, P = 0.017) in comparison to the control group (P = 0.087, P = 0.066) respectively. As for time of recovery, a statistically significant difference was observed in BTX-A group (P < 0.001) and LLLT (P < 0.001) group in comparison to ARA group, which showed the most prolonged duration for reduction of DDwR symptoms. Conclusion We concluded that BTX-A and LLLT could be considered effective alternative treatment modalities to ARA regarding reducing joint pain, clicking, and improving disc position in patients with symptomatic DDwR. Trial registration This prospective double-blinded RCT has been registered at ClinicalTrials.gov with identification number: NCT05194488, 18/1/2022. |
| first_indexed | 2024-04-12T04:14:47Z |
| format | Article |
| id | doaj.art-b93664aca4dd4208a1a0a1098b630c6d |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-12T04:14:47Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-b93664aca4dd4208a1a0a1098b630c6d2022-12-22T03:48:25ZengBMCBMC Oral Health1472-68312022-12-0122111410.1186/s12903-022-02579-3Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trialNermeen A. Rady0Mariam M. Bahgat1Ahmed M. Abdel-Hamid2Prosthodontics Department, Faculty of Dentistry, Alexandria UniversityProsthodontics Department, Faculty of Dentistry, Alexandria UniversityProsthodontics Department, Faculty of Dentistry, Alexandria UniversityAbstract Background Pain and clicking are the primary complaints in patients suffering from temporomandibular joint disc displacement with reduction (DDwR), negatively affecting the patients' quality of life, making the treatment essential. This prospective randomized controlled trial (RCT) was conducted to evaluate the effectiveness of botulinum toxin type-A (BTX-A) and low level laser therapy (LLLT) in comparison to anterior repositioning appliance (ARA) for the treatment of DDwR. Methods A total of 27 patients were randomly allocated to 3 groups; ARA (control group), BTX-A, and LLLT; with 9 patients each. All patients were evaluated before and 3 months after the treatment using a visual analogue scale (VAS) and magnetic resonance imaging (MRI). Results At 3 months follow-up, all groups showed a significant reduction in pain assessed by VAS (P = 0.007). Measured on MRI, there was a significant improvement in disc position and joint space index (JSI) in BTX-A group (P < 0.001, P = 0.011) and LLLT group (P = 0.002, P = 0.017) in comparison to the control group (P = 0.087, P = 0.066) respectively. As for time of recovery, a statistically significant difference was observed in BTX-A group (P < 0.001) and LLLT (P < 0.001) group in comparison to ARA group, which showed the most prolonged duration for reduction of DDwR symptoms. Conclusion We concluded that BTX-A and LLLT could be considered effective alternative treatment modalities to ARA regarding reducing joint pain, clicking, and improving disc position in patients with symptomatic DDwR. Trial registration This prospective double-blinded RCT has been registered at ClinicalTrials.gov with identification number: NCT05194488, 18/1/2022.https://doi.org/10.1186/s12903-022-02579-3Temporomandibular disordersInternal derangementBotulinum toxinPhotobiomodulationLateral pterygoid muscleDC/TMD |
| spellingShingle | Nermeen A. Rady Mariam M. Bahgat Ahmed M. Abdel-Hamid Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trial BMC Oral Health Temporomandibular disorders Internal derangement Botulinum toxin Photobiomodulation Lateral pterygoid muscle DC/TMD |
| title | Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trial |
| title_full | Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trial |
| title_fullStr | Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trial |
| title_full_unstemmed | Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trial |
| title_short | Promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction: a randomized controlled clinical trial |
| title_sort | promising minimally invasive treatment modalities for symptomatic temporomandibular joint disc displacement with reduction a randomized controlled clinical trial |
| topic | Temporomandibular disorders Internal derangement Botulinum toxin Photobiomodulation Lateral pterygoid muscle DC/TMD |
| url | https://doi.org/10.1186/s12903-022-02579-3 |
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