Real pandemic world results of pharmacokinetic-tailored personalized prophylaxis of bleeds in Polish children and adolescents with severe hemophilia A

Real pandemic world results of pharmacokinetic-tailored personalized prophylaxis of bleeds in Polish children and adolescents with severe hemophilia A

IntroductionIn 2020, the new nationwide protocol of prophylaxis in Polish plasma-derived FVIII (pdFVIII) previously treated patients (PTPs) with severe hemophilia A (sHA) was introduced, resulting in the necessity of switching from pdFVIII to recombinant FVIII (octocog-alpha; rFVIII). The study aime...

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Main Authors: Tomasz Urasiński, Klaudia Paczóska, Wanda Badowska, Halina Bobrowska, Łucja Dakowicz, Grzegorz Dobaczewski, Elżbieta Latos-Grażyńska, Grażyna Karolczyk, Anna Klukowska, Andrzej Kołtan, Magdalena Wojdalska, Paweł Łaguna, Maciej Niedźwiedzki, Danuta Pietrys, Julia Radoń-Proskura, Monika Radwańska, Iwona Rurańska, Tomasz Szczepański, Dariusz Wasiński, Irena Woźnica-Karczmarz, Karolina Zielezińska, Aleksandra Królak, Tomasz Ociepa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pediatrics
Subjects:
hemophilia A
annualized bleeding rate
annualized joint bleeding rate
plasma-derived FVIII
recombinant FVIII
bleeding prophylaxis
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2023.1084539/full

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