Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy
Genetic instability can be caused by external factors and may also be associated with intracellular damage. At the same time, there is a large body of research investigating the mechanisms by which genetic instability occurs and demonstrating the relationship between genomic stability and tumors. No...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222014251 |
| _version_ | 1811201812115488768 |
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| author | Shihui Guo Xiao Zhu Ziyuan Huang Chuzhong Wei Jiaao Yu Lin Zhang Jinghua Feng Mingdong Li Zesong Li |
| author_facet | Shihui Guo Xiao Zhu Ziyuan Huang Chuzhong Wei Jiaao Yu Lin Zhang Jinghua Feng Mingdong Li Zesong Li |
| author_sort | Shihui Guo |
| collection | DOAJ |
| description | Genetic instability can be caused by external factors and may also be associated with intracellular damage. At the same time, there is a large body of research investigating the mechanisms by which genetic instability occurs and demonstrating the relationship between genomic stability and tumors. Nowadays, tumorigenesis development is one of the hottest research areas. It is a vital factor affecting tumor treatment. Mechanisms of genomic stability and tumorigenesis development are relatively complex. Researchers have been working on these aspects of research. To explore the research progress of genomic stability and tumorigenesis, development, and treatment, the authors searched PubMed with the keywords ''genome instability'' ''chromosome instability'' ''DNA damage'' ''tumor spread'' and ''cancer treatment''. This extracts the information relevant to this study. Results: This review introduces genomic stability, drivers of tumor development, tumor cell characteristics, tumor metastasis, and tumor treatment. Among them, immunotherapy is more important in tumor treatment, which can effectively inhibit tumor metastasis and kill tumor cells. Breakthroughs in tumorigenesis development studies and discoveries in tumor metastasis will provide new therapeutic techniques. New tumor treatment methods can effectively prevent tumor metastasis and improve the cure rate of tumors. |
| first_indexed | 2024-04-12T02:28:13Z |
| format | Article |
| id | doaj.art-b939c598871843219c6049277796a9ed |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-12T02:28:13Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-b939c598871843219c6049277796a9ed2022-12-22T03:51:54ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157114036Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapyShihui Guo0Xiao Zhu1Ziyuan Huang2Chuzhong Wei3Jiaao Yu4Lin Zhang5Jinghua Feng6Mingdong Li7Zesong Li8Computational Oncology Lab, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, ChinaComputational Oncology Lab, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, ChinaComputational Oncology Lab, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, ChinaComputational Oncology Lab, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, ChinaComputational Oncology Lab, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, ChinaComputational Oncology Lab, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, ChinaComputational Oncology Lab, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, ChinaDepartment of Gastroenterology, Zibo Central Hospital, Zibo 255000, China; Corresponding authors.Guangdong Provincial Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Key Laboratory of Genitourinary Tumor, Department of Urology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital (Shenzhen Institute of Translational Medicine), Shenzhen, China; Corresponding authors.Genetic instability can be caused by external factors and may also be associated with intracellular damage. At the same time, there is a large body of research investigating the mechanisms by which genetic instability occurs and demonstrating the relationship between genomic stability and tumors. Nowadays, tumorigenesis development is one of the hottest research areas. It is a vital factor affecting tumor treatment. Mechanisms of genomic stability and tumorigenesis development are relatively complex. Researchers have been working on these aspects of research. To explore the research progress of genomic stability and tumorigenesis, development, and treatment, the authors searched PubMed with the keywords ''genome instability'' ''chromosome instability'' ''DNA damage'' ''tumor spread'' and ''cancer treatment''. This extracts the information relevant to this study. Results: This review introduces genomic stability, drivers of tumor development, tumor cell characteristics, tumor metastasis, and tumor treatment. Among them, immunotherapy is more important in tumor treatment, which can effectively inhibit tumor metastasis and kill tumor cells. Breakthroughs in tumorigenesis development studies and discoveries in tumor metastasis will provide new therapeutic techniques. New tumor treatment methods can effectively prevent tumor metastasis and improve the cure rate of tumors.http://www.sciencedirect.com/science/article/pii/S0753332222014251Chromosome instabilityDNA damageGenome stabilityTumor metastasisTumor therapy |
| spellingShingle | Shihui Guo Xiao Zhu Ziyuan Huang Chuzhong Wei Jiaao Yu Lin Zhang Jinghua Feng Mingdong Li Zesong Li Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy Biomedicine & Pharmacotherapy Chromosome instability DNA damage Genome stability Tumor metastasis Tumor therapy |
| title | Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy |
| title_full | Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy |
| title_fullStr | Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy |
| title_full_unstemmed | Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy |
| title_short | Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy |
| title_sort | genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy |
| topic | Chromosome instability DNA damage Genome stability Tumor metastasis Tumor therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222014251 |
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