PF74 and Its Novel Derivatives Stabilize Hexameric Lattice of HIV-1 Mature-Like Particles

PF74 and Its Novel Derivatives Stabilize Hexameric Lattice of HIV-1 Mature-Like Particles

A major structural retroviral protein, capsid protein (CA), is able to oligomerize into two different hexameric lattices, which makes this protein a key component for both the early and late stages of HIV-1 replication. During the late stage, the CA protein, as part of the Gag polyprotein precursor,...

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Bibliographic Details
Main Authors: Alžběta Dostálková, Kryštof Škach, Filip Kaufman, Ivana Křížová, Romana Hadravová, Martin Flegel, Tomáš Ruml, Richard Hrabal, Michaela Rumlová
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
HIV-1 CA inhibitor
PF74 derivatives
uncoating
disassembly
Online Access:https://www.mdpi.com/1420-3049/25/8/1895

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