Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review
Primary urethral adenocarcinoma in females is an extremely rare malignancy with unclear origin and only a few retrospective cases have been reported. The controversy continues to exist over the origin of primary urethral adenocarcinoma from periurethral glands (which include the Skene’s glands), ure...
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MDPI AG
2023-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/1/109 |
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| author | Junjie Tian Ting Zhu Zhijie Xu Xiaoyi Chen Yunfei Wu Guanghou Fu Baiye Jin |
| author_facet | Junjie Tian Ting Zhu Zhijie Xu Xiaoyi Chen Yunfei Wu Guanghou Fu Baiye Jin |
| author_sort | Junjie Tian |
| collection | DOAJ |
| description | Primary urethral adenocarcinoma in females is an extremely rare malignancy with unclear origin and only a few retrospective cases have been reported. The controversy continues to exist over the origin of primary urethral adenocarcinoma from periurethral glands (which include the Skene’s glands), urethritis glandularis or intestinal metaplasia. Herein, we report one case of a 49-year-old female with distal urethral adenocarcinoma who presented with obstructive voiding. Abdominal and pelvic CT scans and chest radiology were unremarkable. Biopsy of the mass confirmed urethral adenocarcinoma. The patient underwent partial ureterectomy and was disease-free at the 2-years follow-up period. We also present another extremely rare case of primary urethral adenocarcinoma with mucinous features in a 58-year-old female who initially complained of external urethral orifice itching with painless urethral bleeding and was treated with local excision. The patient has not received any neoadjuvant or adjuvant therapy, and experienced tumor recurrence, inguinal lymph nodes metastasis, and even local iliopsoas metastasis during over 10-years follow-up. In conclusion, our current study emphasizes the importance of imaging studies and biopsy in making an accurate preoperative diagnosis of this rare disease, and further highlights the role of multimodal therapy. A combination of radiotherapy, chemotherapy and surgery is recommended for the optimal local and distant disease control. Moreover, better medical compliance and regular follow-up are required in these patients. |
| first_indexed | 2024-03-09T11:44:46Z |
| format | Article |
| id | doaj.art-b939d90c92b44d81b6debb20e0f4aae2 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T11:44:46Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-b939d90c92b44d81b6debb20e0f4aae22023-11-30T23:24:28ZengMDPI AGMedicina1010-660X1648-91442023-01-0159110910.3390/medicina59010109Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature ReviewJunjie Tian0Ting Zhu1Zhijie Xu2Xiaoyi Chen3Yunfei Wu4Guanghou Fu5Baiye Jin6Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310024, ChinaDepartment of Urology, Jinyun People’s Hospital, Lishui 321400, ChinaDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310024, ChinaDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310024, ChinaDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310024, ChinaDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310024, ChinaDepartment of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310024, ChinaPrimary urethral adenocarcinoma in females is an extremely rare malignancy with unclear origin and only a few retrospective cases have been reported. The controversy continues to exist over the origin of primary urethral adenocarcinoma from periurethral glands (which include the Skene’s glands), urethritis glandularis or intestinal metaplasia. Herein, we report one case of a 49-year-old female with distal urethral adenocarcinoma who presented with obstructive voiding. Abdominal and pelvic CT scans and chest radiology were unremarkable. Biopsy of the mass confirmed urethral adenocarcinoma. The patient underwent partial ureterectomy and was disease-free at the 2-years follow-up period. We also present another extremely rare case of primary urethral adenocarcinoma with mucinous features in a 58-year-old female who initially complained of external urethral orifice itching with painless urethral bleeding and was treated with local excision. The patient has not received any neoadjuvant or adjuvant therapy, and experienced tumor recurrence, inguinal lymph nodes metastasis, and even local iliopsoas metastasis during over 10-years follow-up. In conclusion, our current study emphasizes the importance of imaging studies and biopsy in making an accurate preoperative diagnosis of this rare disease, and further highlights the role of multimodal therapy. A combination of radiotherapy, chemotherapy and surgery is recommended for the optimal local and distant disease control. Moreover, better medical compliance and regular follow-up are required in these patients.https://www.mdpi.com/1648-9144/59/1/109female urethral adenocarcinomamucinous adenocarcinomamultimodal therapyfollow-up |
| spellingShingle | Junjie Tian Ting Zhu Zhijie Xu Xiaoyi Chen Yunfei Wu Guanghou Fu Baiye Jin Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review Medicina female urethral adenocarcinoma mucinous adenocarcinoma multimodal therapy follow-up |
| title | Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review |
| title_full | Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review |
| title_fullStr | Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review |
| title_full_unstemmed | Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review |
| title_short | Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review |
| title_sort | management of primary female urethral adenocarcinoma two rare case reports and literature review |
| topic | female urethral adenocarcinoma mucinous adenocarcinoma multimodal therapy follow-up |
| url | https://www.mdpi.com/1648-9144/59/1/109 |
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