The Influence of Circadian Rhythm on Cancer Cells Targeting and Transfection Efficiency of a Polycation-Drug/Gene Delivery Vector

The Influence of Circadian Rhythm on Cancer Cells Targeting and Transfection Efficiency of a Polycation-Drug/Gene Delivery Vector

The conception of novel anticancer delivery systems and the combination of chronobiology with nanotechnology may provide a powerful tool to optimize cancer therapy. In this work, polyethylenimine (PEI) has been used to complex p53 encoded plasmid DNA (pDNA), and the anticancer drug methotrexate (MTX...

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Bibliographic Details
Main Authors: Tânia Albuquerque, Ana R. Neves, Telma Quintela, Diana Costa
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Polymers
Subjects:
cancer-cells targeting
cancer chronotherapy
circadian clock
drug/gene nanodelivery systems
gene therapy
Online Access:https://www.mdpi.com/2073-4360/14/4/681

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