Interactive relationship between neuronal circuitry and glioma: A narrative review
Glioma is the most common primary central nervous system tumor. Despite extensive basic research on the tumor, the overall therapeutic effect of glioma remains unsatisfactory. Glioma grows within the framework of complex neural circuitry, which influences both neural network and tumor biology. On th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Glioma |
| Subjects: | |
| Online Access: | http://www.jglioma.com/article.asp?issn=2589-6113;year=2022;volume=5;issue=2;spage=43;epage=49;aulast=Liu |
| _version_ | 1828150237589405696 |
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| author | Jie Liu Wei Shi Yu Lin |
| author_facet | Jie Liu Wei Shi Yu Lin |
| author_sort | Jie Liu |
| collection | DOAJ |
| description | Glioma is the most common primary central nervous system tumor. Despite extensive basic research on the tumor, the overall therapeutic effect of glioma remains unsatisfactory. Glioma grows within the framework of complex neural circuitry, which influences both neural network and tumor biology. On the one hand, the growth of gliomas continuously invades and destroys normal neural structures, which stimulate the dynamic remodeling of neural networks to maintain neural function. On the other hand, glioma can also induce neurons to form synaptic connections with it to promote tumor growth. Interventions targeting the interaction between gliomas and the neuronal circuitry provide opportunities for both tumor therapy and neuroplasticity at the same time. Noninvasive brain stimulation (NiBS) technology can actively regulate the excitability of targeted brain regions which can actively induce the remodeling of neural function and may perturb the interference of neuronglioma synapses. This article will review the interaction between gliomas and neural networks, including tumor-induced neuroplasticity, neuron-glioma synaptic connections, and the application and prospect of NiBS techniques. |
| first_indexed | 2024-04-11T21:41:22Z |
| format | Article |
| id | doaj.art-b93e94f2bfb84ac0aa8e5124f7c2bbb8 |
| institution | Directory Open Access Journal |
| issn | 2589-6113 2589-6121 |
| language | English |
| last_indexed | 2024-04-11T21:41:22Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Glioma |
| spelling | doaj.art-b93e94f2bfb84ac0aa8e5124f7c2bbb82022-12-22T04:01:35ZengWolters Kluwer Medknow PublicationsGlioma2589-61132589-61212022-01-0152434910.4103/glioma.glioma_15_22Interactive relationship between neuronal circuitry and glioma: A narrative reviewJie LiuWei ShiYu LinGlioma is the most common primary central nervous system tumor. Despite extensive basic research on the tumor, the overall therapeutic effect of glioma remains unsatisfactory. Glioma grows within the framework of complex neural circuitry, which influences both neural network and tumor biology. On the one hand, the growth of gliomas continuously invades and destroys normal neural structures, which stimulate the dynamic remodeling of neural networks to maintain neural function. On the other hand, glioma can also induce neurons to form synaptic connections with it to promote tumor growth. Interventions targeting the interaction between gliomas and the neuronal circuitry provide opportunities for both tumor therapy and neuroplasticity at the same time. Noninvasive brain stimulation (NiBS) technology can actively regulate the excitability of targeted brain regions which can actively induce the remodeling of neural function and may perturb the interference of neuronglioma synapses. This article will review the interaction between gliomas and neural networks, including tumor-induced neuroplasticity, neuron-glioma synaptic connections, and the application and prospect of NiBS techniques.http://www.jglioma.com/article.asp?issn=2589-6113;year=2022;volume=5;issue=2;spage=43;epage=49;aulast=Liufunctional reorganizationgliomaneural plasticityneuronal circuitryneuron-tumor synapse |
| spellingShingle | Jie Liu Wei Shi Yu Lin Interactive relationship between neuronal circuitry and glioma: A narrative review Glioma functional reorganization glioma neural plasticity neuronal circuitry neuron-tumor synapse |
| title | Interactive relationship between neuronal circuitry and glioma: A narrative review |
| title_full | Interactive relationship between neuronal circuitry and glioma: A narrative review |
| title_fullStr | Interactive relationship between neuronal circuitry and glioma: A narrative review |
| title_full_unstemmed | Interactive relationship between neuronal circuitry and glioma: A narrative review |
| title_short | Interactive relationship between neuronal circuitry and glioma: A narrative review |
| title_sort | interactive relationship between neuronal circuitry and glioma a narrative review |
| topic | functional reorganization glioma neural plasticity neuronal circuitry neuron-tumor synapse |
| url | http://www.jglioma.com/article.asp?issn=2589-6113;year=2022;volume=5;issue=2;spage=43;epage=49;aulast=Liu |
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