Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remove the complement regulator FH from surfaces that...

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Bibliographic Details
Main Authors: Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
complement system
factor H related protein 1
FHR-1
factor H (FH)
FH deregulation
sialic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.615748/full

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