Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy
This study was aimed at assessing the anti-HBs persistence and immune memory 18–19 y after vaccination against hepatitis B in healthy individuals primed as infants or adolescents. We enrolled 405 teenagers (Group A) vaccinated as infants, and 409 young adults (Group B) vaccinated as adolescents. All...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-05-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1264795 |
| _version_ | 1797674570020290560 |
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| author | Luisa Romanò Cristina Galli Catia Tagliacarne Maria Elena Tosti Claudio Velati Laura Fomiatti Maria Chironna Rosa Cristina Coppola Mario Cuccia Rossana Mangione Fosca Marrone Francesco Saverio Negrone Antonino Parlato Carla Maria Zotti Alfonso Mele Alessandro Remo Zanetti the Study Group |
| author_facet | Luisa Romanò Cristina Galli Catia Tagliacarne Maria Elena Tosti Claudio Velati Laura Fomiatti Maria Chironna Rosa Cristina Coppola Mario Cuccia Rossana Mangione Fosca Marrone Francesco Saverio Negrone Antonino Parlato Carla Maria Zotti Alfonso Mele Alessandro Remo Zanetti the Study Group |
| author_sort | Luisa Romanò |
| collection | DOAJ |
| description | This study was aimed at assessing the anti-HBs persistence and immune memory 18–19 y after vaccination against hepatitis B in healthy individuals primed as infants or adolescents. We enrolled 405 teenagers (Group A) vaccinated as infants, and 409 young adults (Group B) vaccinated as adolescents. All vaccinees were tested for anti-HBs and anti-HBc antibodies; those found anti-HBc positive were further tested for HBsAg and HBV DNA. Eight individuals belonging to Group B were positive for anti-HBc alone, and were excluded from analysis. Individuals with anti-HBs concentration ≥ 10 mIU/ml were considered protected while those with anti-HBs concentration <10 mIU/ml were offered a booster dose and re-tested 2 weeks later. Overall, 67.9% individuals showed anti-HBs concentrations ≥ 10 mIU/ml (48.9% in Group A vs 87.0% in Group B, p < 0.001). The antibody geometric mean concentration (GMC) was higher in Group B than in Group A (102.5 mIU/ml vs 6.9 mIU/ml; p < 0.001). When boosted, 94.2% of vaccinees with anti-HBs <10 mIU/ml belonging to Group A and 94.7% to Group B showed an anamnestic response. Post-booster GMCs were similar in both groups (477.9 mIU/ml for Group A vs 710.0 mIU/ml for Group B, p = n.s.). Strong immunological memory persists for at least 18–19 y after immunization of infants or adolescents with a primary course of vaccination. Thus, booster doses are not needed at this time, but additional follow up is required to assess the long-life longevity of protection. |
| first_indexed | 2024-03-11T22:00:57Z |
| format | Article |
| id | doaj.art-b93fa6b382574b3392a462a78604e452 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:00:57Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-b93fa6b382574b3392a462a78604e4522023-09-25T11:02:54ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-05-0113598198510.1080/21645515.2017.12647951264795Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in ItalyLuisa Romanò0Cristina Galli1Catia Tagliacarne2Maria Elena Tosti3Claudio Velati4Laura Fomiatti5Maria Chironna6Rosa Cristina Coppola7Mario Cuccia8Rossana Mangione9Fosca Marrone10Francesco Saverio Negrone11Antonino Parlato12Carla Maria Zotti13Alfonso Mele14Alessandro Remo Zanetti15the Study GroupUniversità degli Studi di MilanoUniversità degli Studi di MilanoUniversità degli Studi di MilanoIstituto Superiore di SanitàServizio di Immunoematologia e Medicina Trasfusionale, Policlinico S Orsola MalpighiServizio di Immunoematologia e Medicina Trasfusionale, ASST della Valtellina e dell'Alto Lario, Presidio di SondrioUniversità di BariMedicina Clinica e Molecolare, Università di CagliariSettore Igiene Pubblica, Servizio di Epidemiologia e Prevenzione, ASP CataniaASP Agrigento, Distretto di LicataPediatria di Comunità, AUSL della Romagna-CesenaASP PotenzaServizio Dipartimentale di Epidemiologia e Prevenzione, ASL Napoli 2 NordUniversità di TorinoIstituto Superiore di SanitàUniversità degli Studi di MilanoThis study was aimed at assessing the anti-HBs persistence and immune memory 18–19 y after vaccination against hepatitis B in healthy individuals primed as infants or adolescents. We enrolled 405 teenagers (Group A) vaccinated as infants, and 409 young adults (Group B) vaccinated as adolescents. All vaccinees were tested for anti-HBs and anti-HBc antibodies; those found anti-HBc positive were further tested for HBsAg and HBV DNA. Eight individuals belonging to Group B were positive for anti-HBc alone, and were excluded from analysis. Individuals with anti-HBs concentration ≥ 10 mIU/ml were considered protected while those with anti-HBs concentration <10 mIU/ml were offered a booster dose and re-tested 2 weeks later. Overall, 67.9% individuals showed anti-HBs concentrations ≥ 10 mIU/ml (48.9% in Group A vs 87.0% in Group B, p < 0.001). The antibody geometric mean concentration (GMC) was higher in Group B than in Group A (102.5 mIU/ml vs 6.9 mIU/ml; p < 0.001). When boosted, 94.2% of vaccinees with anti-HBs <10 mIU/ml belonging to Group A and 94.7% to Group B showed an anamnestic response. Post-booster GMCs were similar in both groups (477.9 mIU/ml for Group A vs 710.0 mIU/ml for Group B, p = n.s.). Strong immunological memory persists for at least 18–19 y after immunization of infants or adolescents with a primary course of vaccination. Thus, booster doses are not needed at this time, but additional follow up is required to assess the long-life longevity of protection.http://dx.doi.org/10.1080/21645515.2017.1264795hepatitis bhbvimmune memorylong-term immunityvaccination |
| spellingShingle | Luisa Romanò Cristina Galli Catia Tagliacarne Maria Elena Tosti Claudio Velati Laura Fomiatti Maria Chironna Rosa Cristina Coppola Mario Cuccia Rossana Mangione Fosca Marrone Francesco Saverio Negrone Antonino Parlato Carla Maria Zotti Alfonso Mele Alessandro Remo Zanetti the Study Group Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy Human Vaccines & Immunotherapeutics hepatitis b hbv immune memory long-term immunity vaccination |
| title | Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy |
| title_full | Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy |
| title_fullStr | Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy |
| title_full_unstemmed | Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy |
| title_short | Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy |
| title_sort | persistence of immunity 18 19 years after vaccination against hepatitis b in 2 cohorts of vaccinees primed as infants or as adolescents in italy |
| topic | hepatitis b hbv immune memory long-term immunity vaccination |
| url | http://dx.doi.org/10.1080/21645515.2017.1264795 |
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