Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screening
ABSTRACT Objective: Oral glucose tolerance testing (OGTT) is the current recommended approach for the diagnosis of gestational diabetes mellitus (GDM). Visfatin is a type of novel adipokine of interest that mostly participates in glucose metabolism and inflammatory processes. We aim to identify a s...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2021-11-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000600747&tlng=en |
| _version_ | 1798022331314995200 |
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| author | Hacer Eroglu İÇLİ Tevfik Berk BİLDACI |
| author_facet | Hacer Eroglu İÇLİ Tevfik Berk BİLDACI |
| author_sort | Hacer Eroglu İÇLİ |
| collection | DOAJ |
| description | ABSTRACT Objective: Oral glucose tolerance testing (OGTT) is the current recommended approach for the diagnosis of gestational diabetes mellitus (GDM). Visfatin is a type of novel adipokine of interest that mostly participates in glucose metabolism and inflammatory processes. We aim to identify a screening technique for GDM using salivary visfatin levels and to establish this technique’s value as a screening method compared to OGTT. Materials and methods: This is a cross-sectional case-control study. The cohort was formed from the saliva samples of pregnant patients in their 24th through 28th weeks of gestation. Patients were divided into two groups depending on their GDM status. OGTT and visfatin test results were compared and subjected to further analysis to establish a cutoff value for visfatin testing. Results: ELISA results indicated a significant difference between patients with GDM compared to patients without GDM; the values were 18.89 ± 9.59 and 12.44 ± 8.75, respectively (p: 0.007). A cutoff value of 10.5 ng/mL can be used to detect GDM with 78% sensitivity and 51% specificity. Conclusion: Salivary visfatin levels were significantly higher in patients with GDM. The existence of a differential in the concentration of visfatin in saliva can be utilized to develop a new screening method for GDM. |
| first_indexed | 2024-04-11T17:28:08Z |
| format | Article |
| id | doaj.art-b94c3d158e4d45cab932ce85906f5776 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-11T17:28:08Z |
| publishDate | 2021-11-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-b94c3d158e4d45cab932ce85906f57762022-12-22T04:12:14ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922021-11-0165674775110.20945/2359-3997000000396Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screeningHacer Eroglu İÇLİhttps://orcid.org/0000-0002-9775-1710Tevfik Berk BİLDACIhttps://orcid.org/0000-0002-6432-6777ABSTRACT Objective: Oral glucose tolerance testing (OGTT) is the current recommended approach for the diagnosis of gestational diabetes mellitus (GDM). Visfatin is a type of novel adipokine of interest that mostly participates in glucose metabolism and inflammatory processes. We aim to identify a screening technique for GDM using salivary visfatin levels and to establish this technique’s value as a screening method compared to OGTT. Materials and methods: This is a cross-sectional case-control study. The cohort was formed from the saliva samples of pregnant patients in their 24th through 28th weeks of gestation. Patients were divided into two groups depending on their GDM status. OGTT and visfatin test results were compared and subjected to further analysis to establish a cutoff value for visfatin testing. Results: ELISA results indicated a significant difference between patients with GDM compared to patients without GDM; the values were 18.89 ± 9.59 and 12.44 ± 8.75, respectively (p: 0.007). A cutoff value of 10.5 ng/mL can be used to detect GDM with 78% sensitivity and 51% specificity. Conclusion: Salivary visfatin levels were significantly higher in patients with GDM. The existence of a differential in the concentration of visfatin in saliva can be utilized to develop a new screening method for GDM.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000600747&tlng=enAdipokinegestational diabetesoral glucose tolerance testingvisfatin |
| spellingShingle | Hacer Eroglu İÇLİ Tevfik Berk BİLDACI Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screening Archives of Endocrinology and Metabolism Adipokine gestational diabetes oral glucose tolerance testing visfatin |
| title | Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screening |
| title_full | Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screening |
| title_fullStr | Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screening |
| title_full_unstemmed | Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screening |
| title_short | Measuring visfatin levels in saliva: an alternative approach to gestational diabetes screening |
| title_sort | measuring visfatin levels in saliva an alternative approach to gestational diabetes screening |
| topic | Adipokine gestational diabetes oral glucose tolerance testing visfatin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000600747&tlng=en |
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