Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents
A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalar...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2003-07-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/8/7/556/ |
| _version_ | 1819230908215984128 |
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| author | Christoph Boss Marianne Huerzeler Reto Mueller |
| author_facet | Christoph Boss Marianne Huerzeler Reto Mueller |
| author_sort | Christoph Boss |
| collection | DOAJ |
| description | A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II. |
| first_indexed | 2024-12-23T11:36:32Z |
| format | Article |
| id | doaj.art-b94c72606e224278be64ef82daac0acf |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-23T11:36:32Z |
| publishDate | 2003-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b94c72606e224278be64ef82daac0acf2022-12-21T17:48:38ZengMDPI AGMolecules1420-30492003-07-018755656410.3390/80700556Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial AgentsChristoph BossMarianne HuerzelerReto MuellerA new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II.http://www.mdpi.com/1420-3049/8/7/556/MalariaPlasmepsin IIReductive AminationSuzuki Coupling |
| spellingShingle | Christoph Boss Marianne Huerzeler Reto Mueller Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents Molecules Malaria Plasmepsin II Reductive Amination Suzuki Coupling |
| title | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_full | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_fullStr | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_full_unstemmed | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_short | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_sort | synthesis of plasmepsin ii inhibitors a¢a€a potential antimalarial agents |
| topic | Malaria Plasmepsin II Reductive Amination Suzuki Coupling |
| url | http://www.mdpi.com/1420-3049/8/7/556/ |
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