Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitisation.

Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitisation.

Stress is known to modulate sensitisation to repeated psychostimulant exposure. However, there is no direct evidence linking glucocorticoids and sensitisation achieved by repeated administration of the NMDA receptor antagonist MK-801. We tested the hypothesis that co-administration of RU486, a gluco...

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Bibliographic Details
Main Authors: Emilia M Lefevre, Gregory A Medley, Timothy Reeks, Suzy Alexander, Thomas H J Burne, Darryl W Eyles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5400269?pdf=render

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