The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia
Introduction Schizophrenia (SZ) is associated with changes in haematological parameters related to low-grade inflammation state and could be amplified via oxidative stress (OS) related mechanisms. Although studies confirm this relationship, the results could be cofounded by patients’ treatment. Ob...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822020508/type/journal_article |
| _version_ | 1797617225273704448 |
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| author | J. Rog M. Dzikowski D. Juchnowicz N. Waszkiewicz A. Zalewska M. Maciejczyk H. Karakula-Juchnowicz |
| author_facet | J. Rog M. Dzikowski D. Juchnowicz N. Waszkiewicz A. Zalewska M. Maciejczyk H. Karakula-Juchnowicz |
| author_sort | J. Rog |
| collection | DOAJ |
| description |
Introduction
Schizophrenia (SZ) is associated with changes in haematological parameters related to low-grade inflammation state and could be amplified via oxidative stress (OS) related mechanisms. Although studies confirm this relationship, the results could be cofounded by patients’ treatment.
Objectives
The study aimed to assess the connection between venous blood count and OS in drug-naïve first-episode SZ patients.
Methods
The study consisted of 24 SZ drug-naïve patients during first episode of psychosis (median age: 22 years), and 31 healthy individuals (HC) as a control group (median age: 28 years). The examination included clinical data, OS parameters (enzymatic and non-enzymatic antioxidants), peripheral blood counts.
Results
We did not find differences between SZ and HC in blood count parameters (p>0.05). In patients group, white blood cells (WBC), neutrophils and neutrophils-to-lymphocyte ratio (NLR) were positively related with the severity of positive symptoms (R=0.59, R=0.53, R=0.50; p<0.05, respectively). WBC was related to superoxide dismutase (SOD-1) levels (HC: R=-0.36, SZ: R=0.70; p<0.05). Neutrophils were positively related to catalase (CAT) (R=0.52; p<0.05) and ferric reducing antioxidant power (FRAP) (R=0.61; p<0.05), but only in the patients’ group. There was a positive relationship between NLR and CAT (R=0.45; p<0.05) in the SZ group.
Conclusions
The results indicate potential connection and interplay between OS and blood count parameters in the onset of psychotic episode. Further studies on a larger group of patients are needed.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:52:49Z |
| format | Article |
| id | doaj.art-b94da3f8b26c4422ace500955dec7aa0 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:52:49Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-b94da3f8b26c4422ace500955dec7aa02023-11-17T05:06:30ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S793S79310.1192/j.eurpsy.2022.2050The importance of blood count and oxidative stress in the drug-naïve first episode schizophreniaJ. Rog0M. Dzikowski1D. Juchnowicz2N. Waszkiewicz3A. Zalewska4M. Maciejczyk5H. Karakula-Juchnowicz6Medical University of Lublin, 1st Department Of Psychiatry, Psychotherapy And Early Intervention, Lublin, PolandMedical University of Lublin, 1st Department Of Psychiatry, Psychotherapy And Early Intervention, Lublin, PolandMedical University of Lublin, Department Of Psychiatric Nursing, Lublin, PolandMedical University of Bialystok, Department Of Psychiatry, Białystok, PolandMedical University of Bialystok, Experimental Dentistry Laboratory And Department Of Restorative Dentistry, Bialystok, PolandMedical University of Bialystok, Department Of Hygiene, Epidemiology And Ergonomics, Białystok, PolandMedical University of Lublin, 1st Department Of Psychiatry, Psychotherapy And Early Intervention, Lublin, Poland Introduction Schizophrenia (SZ) is associated with changes in haematological parameters related to low-grade inflammation state and could be amplified via oxidative stress (OS) related mechanisms. Although studies confirm this relationship, the results could be cofounded by patients’ treatment. Objectives The study aimed to assess the connection between venous blood count and OS in drug-naïve first-episode SZ patients. Methods The study consisted of 24 SZ drug-naïve patients during first episode of psychosis (median age: 22 years), and 31 healthy individuals (HC) as a control group (median age: 28 years). The examination included clinical data, OS parameters (enzymatic and non-enzymatic antioxidants), peripheral blood counts. Results We did not find differences between SZ and HC in blood count parameters (p>0.05). In patients group, white blood cells (WBC), neutrophils and neutrophils-to-lymphocyte ratio (NLR) were positively related with the severity of positive symptoms (R=0.59, R=0.53, R=0.50; p<0.05, respectively). WBC was related to superoxide dismutase (SOD-1) levels (HC: R=-0.36, SZ: R=0.70; p<0.05). Neutrophils were positively related to catalase (CAT) (R=0.52; p<0.05) and ferric reducing antioxidant power (FRAP) (R=0.61; p<0.05), but only in the patients’ group. There was a positive relationship between NLR and CAT (R=0.45; p<0.05) in the SZ group. Conclusions The results indicate potential connection and interplay between OS and blood count parameters in the onset of psychotic episode. Further studies on a larger group of patients are needed. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822020508/type/journal_articleOxidative stressFirst Episode Psychosiswhite blood cellsdrug-naïve |
| spellingShingle | J. Rog M. Dzikowski D. Juchnowicz N. Waszkiewicz A. Zalewska M. Maciejczyk H. Karakula-Juchnowicz The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia European Psychiatry Oxidative stress First Episode Psychosis white blood cells drug-naïve |
| title | The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia |
| title_full | The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia |
| title_fullStr | The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia |
| title_full_unstemmed | The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia |
| title_short | The importance of blood count and oxidative stress in the drug-naïve first episode schizophrenia |
| title_sort | importance of blood count and oxidative stress in the drug naive first episode schizophrenia |
| topic | Oxidative stress First Episode Psychosis white blood cells drug-naïve |
| url | https://www.cambridge.org/core/product/identifier/S0924933822020508/type/journal_article |
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