Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4

Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4

Abstract Mechanical loading to the bone is known to be beneficial for bone homeostasis and for suppressing tumor-induced osteolysis in the loaded bone. However, whether loading to a weight-bearing hind limb can inhibit distant tumor growth in the brain is unknown. We examined the possibility of bone...

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Bibliographic Details
Main Authors:	Yao Fan, Rongrong Zha, Tomohiko Sano, Xinyu Zhao, Shengzhi Liu, Mark D. Woollam, Di Wu, Xun Sun, Kexin Li, Motoki Egi, Fangjia Li, Kazumasa Minami, Amanda P. Siegel, Takashi Horiuchi, Jing Liu, Mangilal Agarwal, Akihiro Sudo, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokota
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Bone Research
Online Access:	https://doi.org/10.1038/s41413-021-00144-2

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