Plasma levels of neurotrophic factors are not associated with the severity of depression
Depression is one of the most common mental illnesses. Impaired neurogenesis is observed in depression. Studying the concentration of biochemical indicators in the blood that may be involved in the pathogenesis of depression, looking for associations with the severity of depressive symptoms can be u...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Eco-Vector
2021-12-01
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| Series: | Consortium Psychiatricum |
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| Online Access: | https://consortium-psy.com/jour/article/viewFile/110/pdf |
| _version_ | 1811329482294820864 |
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| author | Yana A. Zorkina Timur S. Syunyakov Olga V. Abramova Roman A. Yunes Aleksey V. Pavlichenko Konstantin A. Pavlov Elena B. Khobta Daria A. Susloparova Grigory Y. Tsarapkin Denis S. Andreyuk Valery N. Danilenko Olga I. Gurina Anna Y. Morozova |
| author_facet | Yana A. Zorkina Timur S. Syunyakov Olga V. Abramova Roman A. Yunes Aleksey V. Pavlichenko Konstantin A. Pavlov Elena B. Khobta Daria A. Susloparova Grigory Y. Tsarapkin Denis S. Andreyuk Valery N. Danilenko Olga I. Gurina Anna Y. Morozova |
| author_sort | Yana A. Zorkina |
| collection | DOAJ |
| description | Depression is one of the most common mental illnesses. Impaired neurogenesis is observed in depression. Studying the concentration of biochemical indicators in the blood that may be involved in the pathogenesis of depression, looking for associations with the severity of depressive symptoms can be useful as an objective diagnosis of the disease and predicting the severity of the pathology. We determined plasma concentrations of the monoamine neurotransmitters serotonin and dopamine, and neurotrophic factors involved in neurogenesis (BDNF, CDNF and neuropeptide Y) in depressed patients and healthy volunteers with the same socio-demographic parameters using enzyme immunoassay and mass spectrometry. All study participants were administered the Hamilton Depression Scale (HAMD), the Generalized Anxiety Disorder Questionnaire (GAD-7), and the Center for Epidemiological Studies (CES-D). The cumulative scores on the three scales examined were significantly higher in depressed patients than in controls. The concentration of serotonin, dopamine, BDNF, CDNF, and neuropeptide Y in plasma did not differ between the subject groups and was not associated with the scores on the scales. Positive correlations were found between the content of neuropeptide Y and serotonin, BDNF and CDNF in blood plasma. Thus, although these markers are related to the pathophysiology of depression, they do not correlate with the severity of symptomatology and possibly in plasma cannot reflect processes occurring in the brain. |
| first_indexed | 2024-04-13T15:44:39Z |
| format | Article |
| id | doaj.art-b94f325f978c417cb4e885aa7aabb0e7 |
| institution | Directory Open Access Journal |
| issn | 2712-7672 2713-2919 |
| language | English |
| last_indexed | 2024-04-13T15:44:39Z |
| publishDate | 2021-12-01 |
| publisher | Eco-Vector |
| record_format | Article |
| series | Consortium Psychiatricum |
| spelling | doaj.art-b94f325f978c417cb4e885aa7aabb0e72022-12-22T02:41:01ZengEco-VectorConsortium Psychiatricum2712-76722713-29192021-12-0124132210.17816/CP11051Plasma levels of neurotrophic factors are not associated with the severity of depressionYana A. Zorkina0https://orcid.org/0000-0003-0247-2717Timur S. Syunyakov1https://orcid.org/0000-0002-4334-1601Olga V. Abramova2https://orcid.org/0000-0001-8793-1833Roman A. Yunes3https://orcid.org/0000-0001-6283-6258Aleksey V. Pavlichenko4https://orcid.org/0000-0003-2742-552XKonstantin A. Pavlov5Elena B. Khobta6https://orcid.org/0000-0002-4501-8576Daria A. Susloparova7https://orcid.org/0000-0002-8505-8310Grigory Y. Tsarapkin8Denis S. Andreyuk9https://orcid.org/0000-0002-3349-5391Valery N. Danilenko10https://orcid.org/0000-0001-5780-0621Olga I. Gurina11https://orcid.org/0000-0001-6942-5531Anna Y. Morozova12https://orcid.org/0000-0002-8681-5299V. Serbsky National Medical Research Centre of Psychiatry and NarcologyV. Serbsky National Medical Research Centre of Psychiatry and NarcologyV. Serbsky National Medical Research Centre of Psychiatry and NarcologyVavilov Institute of General Genetics, Russian Academy of SciencesMental Health Clinic No.1 named after N.A. AlexeevV. Serbsky National Medical Research Centre of Psychiatry and NarcologyMental Health Clinic No.1 named after N.A. AlexeevMental Health Clinic No.1 named after N.A. AlexeevResearch Clinical Institute of Otorhinolaryngology of L.I. Svelzhevsky Department of Health of MoscowMental Health Clinic No.1 named after N.A. AlexeevVavilov Institute of General Genetics, Russian Academy of SciencesV. Serbsky National Medical Research Centre of Psychiatry and NarcologyV. Serbsky National Medical Research Centre of Psychiatry and NarcologyDepression is one of the most common mental illnesses. Impaired neurogenesis is observed in depression. Studying the concentration of biochemical indicators in the blood that may be involved in the pathogenesis of depression, looking for associations with the severity of depressive symptoms can be useful as an objective diagnosis of the disease and predicting the severity of the pathology. We determined plasma concentrations of the monoamine neurotransmitters serotonin and dopamine, and neurotrophic factors involved in neurogenesis (BDNF, CDNF and neuropeptide Y) in depressed patients and healthy volunteers with the same socio-demographic parameters using enzyme immunoassay and mass spectrometry. All study participants were administered the Hamilton Depression Scale (HAMD), the Generalized Anxiety Disorder Questionnaire (GAD-7), and the Center for Epidemiological Studies (CES-D). The cumulative scores on the three scales examined were significantly higher in depressed patients than in controls. The concentration of serotonin, dopamine, BDNF, CDNF, and neuropeptide Y in plasma did not differ between the subject groups and was not associated with the scores on the scales. Positive correlations were found between the content of neuropeptide Y and serotonin, BDNF and CDNF in blood plasma. Thus, although these markers are related to the pathophysiology of depression, they do not correlate with the severity of symptomatology and possibly in plasma cannot reflect processes occurring in the brain.https://consortium-psy.com/jour/article/viewFile/110/pdfdepressionhamdces-dgad7bdnfcdnfneuropeptide y |
| spellingShingle | Yana A. Zorkina Timur S. Syunyakov Olga V. Abramova Roman A. Yunes Aleksey V. Pavlichenko Konstantin A. Pavlov Elena B. Khobta Daria A. Susloparova Grigory Y. Tsarapkin Denis S. Andreyuk Valery N. Danilenko Olga I. Gurina Anna Y. Morozova Plasma levels of neurotrophic factors are not associated with the severity of depression Consortium Psychiatricum depression hamd ces-d gad7 bdnf cdnf neuropeptide y |
| title | Plasma levels of neurotrophic factors are not associated with the severity of depression |
| title_full | Plasma levels of neurotrophic factors are not associated with the severity of depression |
| title_fullStr | Plasma levels of neurotrophic factors are not associated with the severity of depression |
| title_full_unstemmed | Plasma levels of neurotrophic factors are not associated with the severity of depression |
| title_short | Plasma levels of neurotrophic factors are not associated with the severity of depression |
| title_sort | plasma levels of neurotrophic factors are not associated with the severity of depression |
| topic | depression hamd ces-d gad7 bdnf cdnf neuropeptide y |
| url | https://consortium-psy.com/jour/article/viewFile/110/pdf |
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