The identities of insulin signaling pathway are affected by overexpression of Tau and its phosphorylation form

The identities of insulin signaling pathway are affected by overexpression of Tau and its phosphorylation form

IntroductionHyperphosphorylated Tau formed neurofibrillary tangles was one of the major neuropathological hallmarks of Alzheimer’s disease (AD). Dysfunctional insulin signaling in brain is involved in AD. However, the effect of Tau pathology on brain insulin resistance remains unclear. This study ex...

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Bibliographic Details
Main Authors: Ningtian Ma, Yuyang Liang, Lingyun Yue, Pu Liu, Yuxia Xu, Cuiqing Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
Tau
pseudo-phosphorylation
insulin signaling pathway
lonafarnib
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1057281/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.1057281/full

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