Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes
A series of 6-aryl substituted pyrimidine azodyes were synthesized by coupling of phenyl pyrimidine 2-amine with different aromatic amines. The synthetic compounds were screened for their in-vitro antioxidant and anti-inflammatory activities. The characterization of the synthesized compounds was car...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535220303841 |
| _version_ | 1819055875017408512 |
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| author | Aziz Unnisa Amr S. Abouzied Anupama Baratam K.N.V. Chenchu Lakshmi Talib Hussain Rama Devi Kunduru Humera Banu Syeda Bushra Fatima Arshad Hussian Kesavanarayanan Krishnan Selvarajan |
| author_facet | Aziz Unnisa Amr S. Abouzied Anupama Baratam K.N.V. Chenchu Lakshmi Talib Hussain Rama Devi Kunduru Humera Banu Syeda Bushra Fatima Arshad Hussian Kesavanarayanan Krishnan Selvarajan |
| author_sort | Aziz Unnisa |
| collection | DOAJ |
| description | A series of 6-aryl substituted pyrimidine azodyes were synthesized by coupling of phenyl pyrimidine 2-amine with different aromatic amines. The synthetic compounds were screened for their in-vitro antioxidant and anti-inflammatory activities. The characterization of the synthesized compounds was carried out by IR, 1H NMR, 13C NMR and Mass spectrophotometry. Computational study of designed compounds was done by OCHEM, Molinspiration cheminformatics, Datawarrior, and Swiss ADME. DPPH assay was used to determine the antioxidant activity and heat hemolysis method for anti-inflammatory activity. |
| first_indexed | 2024-12-21T13:14:28Z |
| format | Article |
| id | doaj.art-b951a1952539421fb4baff8025f7d135 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-21T13:14:28Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-b951a1952539421fb4baff8025f7d1352022-12-21T19:02:47ZengElsevierArabian Journal of Chemistry1878-53522020-12-01131286388649Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyesAziz Unnisa0Amr S. Abouzied1 Anupama Baratam2K.N.V. Chenchu Lakshmi3Talib Hussain4Rama Devi Kunduru5Humera Banu6Syeda Bushra Fatima7Arshad Hussian8Kesavanarayanan Krishnan Selvarajan9Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, Saudi Arabia; Corresponding author.Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, Saudi Arabia; National Organization for Drug Control & Research, Cairo, EgyptDepartment of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Andhra Pradesh, IndiaDepartment of Pharmaceutical Chemistry, QIS College of Pharmacy, Andhra Pradesh, IndiaDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail, Saudi ArabiaDepartment of Biology, College of Sciences, University of Hail, Hail, Saudi ArabiaDepartment of Nutrition, College of Applied Medicine, University of Hail, Hail, Saudi ArabiaDepartment of Nutrition, College of Applied Medicine, University of Hail, Hail, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, University of Hail, Hail, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail, Saudi ArabiaA series of 6-aryl substituted pyrimidine azodyes were synthesized by coupling of phenyl pyrimidine 2-amine with different aromatic amines. The synthetic compounds were screened for their in-vitro antioxidant and anti-inflammatory activities. The characterization of the synthesized compounds was carried out by IR, 1H NMR, 13C NMR and Mass spectrophotometry. Computational study of designed compounds was done by OCHEM, Molinspiration cheminformatics, Datawarrior, and Swiss ADME. DPPH assay was used to determine the antioxidant activity and heat hemolysis method for anti-inflammatory activity.http://www.sciencedirect.com/science/article/pii/S1878535220303841Pyrimidine azo dyesDPPH assayHeat hemolysisBOILED egg |
| spellingShingle | Aziz Unnisa Amr S. Abouzied Anupama Baratam K.N.V. Chenchu Lakshmi Talib Hussain Rama Devi Kunduru Humera Banu Syeda Bushra Fatima Arshad Hussian Kesavanarayanan Krishnan Selvarajan Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes Arabian Journal of Chemistry Pyrimidine azo dyes DPPH assay Heat hemolysis BOILED egg |
| title | Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes |
| title_full | Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes |
| title_fullStr | Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes |
| title_full_unstemmed | Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes |
| title_short | Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes |
| title_sort | design synthesis characterization computational study and in vitro antioxidant and anti inflammatory activities of few novel 6 aryl substituted pyrimidine azo dyes |
| topic | Pyrimidine azo dyes DPPH assay Heat hemolysis BOILED egg |
| url | http://www.sciencedirect.com/science/article/pii/S1878535220303841 |
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