Domperidone Protects Cells from Intoxication with <i>Clostridioides difficile</i> Toxins by Inhibiting Hsp70-Assisted Membrane Translocation

Domperidone Protects Cells from Intoxication with <i>Clostridioides difficile</i> Toxins by Inhibiting Hsp70-Assisted Membrane Translocation

<i>Clostridioides difficile</i> infections cause severe symptoms ranging from diarrhea to pseudomembranous colitis due to the secretion of AB-toxins, TcdA and TcdB. Both toxins are taken up into cells through receptor-mediated endocytosis, autoproteolytic processing and translocation of...

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Bibliographic Details
Main Authors: Maria Braune-Yan, Jinfang Jia, Mary Wahba, Johannes Schmid, Panagiotis Papatheodorou, Holger Barth, Katharina Ernst
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Toxins
Subjects:
toxin uptake
chaperones
Hsp70
domperidone
<i>Clostridioides difficile</i> toxins
toxin inhibitors
Online Access:https://www.mdpi.com/2072-6651/15/6/384

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