Qualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference center
Abstract Objective: to evaluate the efficacy of US, both qualitatively and semi-quantitatively, in the selection of treatment for the Covid-19 patient, using patient triage as the gold standard. Methods: Patients admitted to the Covid-19 clinic to be treated with monoclonal antibodies (mAb) or retro...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13027-023-00515-w |
| _version_ | 1797818165143535616 |
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| author | Vincenza Granata Roberta Fusco Alberta Villanacci Francesca Grassi Roberta Grassi Federica Di Stefano Ada Petrone Nicoletta Fusco Stefania Ianniello |
| author_facet | Vincenza Granata Roberta Fusco Alberta Villanacci Francesca Grassi Roberta Grassi Federica Di Stefano Ada Petrone Nicoletta Fusco Stefania Ianniello |
| author_sort | Vincenza Granata |
| collection | DOAJ |
| description | Abstract Objective: to evaluate the efficacy of US, both qualitatively and semi-quantitatively, in the selection of treatment for the Covid-19 patient, using patient triage as the gold standard. Methods: Patients admitted to the Covid-19 clinic to be treated with monoclonal antibodies (mAb) or retroviral treatment and undergoing lung ultrasound (US) were selected from the radiological data set between December 2021 and May 2022 according to the following inclusion criteria: patients with proven Omicron variant and Delta Covid-19 infection; patients with known Covid-19 vaccination with at least two doses. Lung US (LUS) was performed by experienced radiologists. The presence, location, and distribution of abnormalities, such as B-lines, thickening or ruptures of the pleural line, consolidations, and air bronchograms, were evaluated. The anomalous findings in each scan were classified according to the LUS scoring system. Nonparametric statistical tests were performed. Results: The LUS score median value in the patients with Omicron variant was 1.5 (1–20) while the LUS score median value in the patients with Delta variant was 7 (3–24). A difference statistically significant was observed for LUS score values among the patients with Delta variant between the two US examinations (p value = 0.045 at Kruskal Wallis test). There was a difference in median LUS score values between hospitalized and non-hospitalized patients for both the Omicron and Delta groups (p value = 0.02 on the Kruskal Wallis test). For Delta patients groups the sensitivity, specificity, positive and negative predictive values, considering a value of 14 for LUS score for the hospitalization, were of 85.29%, 44.44%, 85.29% and 76.74% respectively. Conclusions: LUS is an interesting diagnostic tool in the context of Covid-19, it could allow to identify the typical pattern of diffuse interstitial pulmonary syndrome and could guide the correct management of patients. |
| first_indexed | 2024-03-13T09:05:07Z |
| format | Article |
| id | doaj.art-b9554e3106be4cb59dc5dd574fedf7aa |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-03-13T09:05:07Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-b9554e3106be4cb59dc5dd574fedf7aa2023-05-28T11:08:58ZengBMCInfectious Agents and Cancer1750-93782023-05-0118111310.1186/s13027-023-00515-wQualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference centerVincenza Granata0Roberta Fusco1Alberta Villanacci2Francesca Grassi3Roberta Grassi4Federica Di Stefano5Ada Petrone6Nicoletta Fusco7Stefania Ianniello8Division of Radiology, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”Medical Oncology Division, Igea SpADepartment of Radiology and Diagnostic Imaging, National Institute for Infectious Diseases IRCCS Lazzaro SpallanzaniDivision of Radiology, “Università degli Studi della Campania Luigi Vanvitelli”Division of Radiology, “Università degli Studi della Campania Luigi Vanvitelli”Department of Radiology and Diagnostic Imaging, National Institute for Infectious Diseases IRCCS Lazzaro SpallanzaniDepartment of Radiology and Diagnostic Imaging, National Institute for Infectious Diseases IRCCS Lazzaro SpallanzaniDepartment of Radiology and Diagnostic Imaging, National Institute for Infectious Diseases IRCCS Lazzaro SpallanzaniDepartment of Radiology and Diagnostic Imaging, National Institute for Infectious Diseases IRCCS Lazzaro SpallanzaniAbstract Objective: to evaluate the efficacy of US, both qualitatively and semi-quantitatively, in the selection of treatment for the Covid-19 patient, using patient triage as the gold standard. Methods: Patients admitted to the Covid-19 clinic to be treated with monoclonal antibodies (mAb) or retroviral treatment and undergoing lung ultrasound (US) were selected from the radiological data set between December 2021 and May 2022 according to the following inclusion criteria: patients with proven Omicron variant and Delta Covid-19 infection; patients with known Covid-19 vaccination with at least two doses. Lung US (LUS) was performed by experienced radiologists. The presence, location, and distribution of abnormalities, such as B-lines, thickening or ruptures of the pleural line, consolidations, and air bronchograms, were evaluated. The anomalous findings in each scan were classified according to the LUS scoring system. Nonparametric statistical tests were performed. Results: The LUS score median value in the patients with Omicron variant was 1.5 (1–20) while the LUS score median value in the patients with Delta variant was 7 (3–24). A difference statistically significant was observed for LUS score values among the patients with Delta variant between the two US examinations (p value = 0.045 at Kruskal Wallis test). There was a difference in median LUS score values between hospitalized and non-hospitalized patients for both the Omicron and Delta groups (p value = 0.02 on the Kruskal Wallis test). For Delta patients groups the sensitivity, specificity, positive and negative predictive values, considering a value of 14 for LUS score for the hospitalization, were of 85.29%, 44.44%, 85.29% and 76.74% respectively. Conclusions: LUS is an interesting diagnostic tool in the context of Covid-19, it could allow to identify the typical pattern of diffuse interstitial pulmonary syndrome and could guide the correct management of patients.https://doi.org/10.1186/s13027-023-00515-wUltrasound assessmentCovid-19Delta variantOmicron variant |
| spellingShingle | Vincenza Granata Roberta Fusco Alberta Villanacci Francesca Grassi Roberta Grassi Federica Di Stefano Ada Petrone Nicoletta Fusco Stefania Ianniello Qualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference center Infectious Agents and Cancer Ultrasound assessment Covid-19 Delta variant Omicron variant |
| title | Qualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference center |
| title_full | Qualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference center |
| title_fullStr | Qualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference center |
| title_full_unstemmed | Qualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference center |
| title_short | Qualitative and semi-quantitative ultrasound assessment in delta and Omicron Covid-19 patients: data from high volume reference center |
| title_sort | qualitative and semi quantitative ultrasound assessment in delta and omicron covid 19 patients data from high volume reference center |
| topic | Ultrasound assessment Covid-19 Delta variant Omicron variant |
| url | https://doi.org/10.1186/s13027-023-00515-w |
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