MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health
Mammalian reproductive health affects the entire reproductive cycle starting with the ovarian function through implantation and fetal growth. Various environmental and physiological factors contribute to disturbed reproductive health status leading to infertility problems in mammalian species. In th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/2/938 |
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| author | Samuel Gebremedhn Asghar Ali Munir Hossain Michael Hoelker Dessie Salilew-Wondim Russell V. Anthony Dawit Tesfaye |
| author_facet | Samuel Gebremedhn Asghar Ali Munir Hossain Michael Hoelker Dessie Salilew-Wondim Russell V. Anthony Dawit Tesfaye |
| author_sort | Samuel Gebremedhn |
| collection | DOAJ |
| description | Mammalian reproductive health affects the entire reproductive cycle starting with the ovarian function through implantation and fetal growth. Various environmental and physiological factors contribute to disturbed reproductive health status leading to infertility problems in mammalian species. In the last couple of decades a significant number of studies have been conducted to investigate the transcriptome of reproductive tissues and organs in relation to the various reproductive health issues including endometritis, polycystic ovarian syndrome (PCOS), intrauterine growth restriction (IUGR), preeclampsia, and various age-associated reproductive disorders. Among others, the post-transcriptional regulation of genes by small noncoding miRNAs contributes to the observed transcriptome dysregulation associated with reproductive pathophysiological conditions. MicroRNAs as a class of non-coding RNAs are also known to be involved in various pathophysiological conditions either in cellular cytoplasm or they can be released to the extracellular fluid via membrane-bounded extracellular vesicles and proteins. The present review summarizes the cellular and extracellular miRNAs and their association with the etiology of major reproductive pathologies including PCOS, endometritis, IUGR and age-associated disorders in various mammalian species. |
| first_indexed | 2024-03-09T04:22:16Z |
| format | Article |
| id | doaj.art-b955d909420f4ecbb45d496cb151406d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:22:16Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b955d909420f4ecbb45d496cb151406d2023-12-03T13:46:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122293810.3390/ijms22020938MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive HealthSamuel Gebremedhn0Asghar Ali1Munir Hossain2Michael Hoelker3Dessie Salilew-Wondim4Russell V. Anthony5Dawit Tesfaye6Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, 3051 Rampart Rd, Fort Collins, CO 80523, USAAnimal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, 3051 Rampart Rd, Fort Collins, CO 80523, USADepartment of Animal Breeding and Genetics, Bangladesh Agricultural University, Mymensingh 2202, BangladeshInstitute of Animal Sciences, Department of Animal Breeding and Husbandry, University of Bonn, 53115 Bonn, GermanyInstitute of Animal Sciences, Department of Animal Breeding and Husbandry, University of Bonn, 53115 Bonn, GermanyAnimal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, 3051 Rampart Rd, Fort Collins, CO 80523, USAAnimal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, 3051 Rampart Rd, Fort Collins, CO 80523, USAMammalian reproductive health affects the entire reproductive cycle starting with the ovarian function through implantation and fetal growth. Various environmental and physiological factors contribute to disturbed reproductive health status leading to infertility problems in mammalian species. In the last couple of decades a significant number of studies have been conducted to investigate the transcriptome of reproductive tissues and organs in relation to the various reproductive health issues including endometritis, polycystic ovarian syndrome (PCOS), intrauterine growth restriction (IUGR), preeclampsia, and various age-associated reproductive disorders. Among others, the post-transcriptional regulation of genes by small noncoding miRNAs contributes to the observed transcriptome dysregulation associated with reproductive pathophysiological conditions. MicroRNAs as a class of non-coding RNAs are also known to be involved in various pathophysiological conditions either in cellular cytoplasm or they can be released to the extracellular fluid via membrane-bounded extracellular vesicles and proteins. The present review summarizes the cellular and extracellular miRNAs and their association with the etiology of major reproductive pathologies including PCOS, endometritis, IUGR and age-associated disorders in various mammalian species.https://www.mdpi.com/1422-0067/22/2/938miRNAsendometritisPCOSageingfertility |
| spellingShingle | Samuel Gebremedhn Asghar Ali Munir Hossain Michael Hoelker Dessie Salilew-Wondim Russell V. Anthony Dawit Tesfaye MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health International Journal of Molecular Sciences miRNAs endometritis PCOS ageing fertility |
| title | MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health |
| title_full | MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health |
| title_fullStr | MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health |
| title_full_unstemmed | MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health |
| title_short | MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health |
| title_sort | microrna mediated gene regulatory mechanisms in mammalian female reproductive health |
| topic | miRNAs endometritis PCOS ageing fertility |
| url | https://www.mdpi.com/1422-0067/22/2/938 |
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