Review: Hearing Loss Genetics
It has been estimated that approximately one in 1000 live births suffer from profound deafness, and greater than 50% of this group is genetic etiology. So far more than 300 different genetic conditions responsible for deafness have been reported that among them 70% are non-syndromic and the rest are...
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| Format: | Article |
| Language: | fas |
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University of Social Welfare and Rehabilitation Sciences
2005-04-01
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| Series: | Journal of Rehabilitation |
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| Online Access: | http://rehabilitationj.uswr.ac.ir/browse.php?a_code=A-10-1-99&slc_lang=en&sid=1 |
| _version_ | 1819148855631937536 |
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| author | Hossein Najm-Abadi Kimia Kahrizi |
| author_facet | Hossein Najm-Abadi Kimia Kahrizi |
| author_sort | Hossein Najm-Abadi |
| collection | DOAJ |
| description | It has been estimated that approximately one in 1000 live births suffer from profound deafness, and greater than 50% of this group is genetic etiology. So far more than 300 different genetic conditions responsible for deafness have been reported that among them 70% are non-syndromic and the rest are syndromic. Non-syndromic and syndromic hearing loss may be divided into Autosomal dominant (DFNA), Autosomal recessive (DFNB), X-linked (DFN), and mitochondrial. Approximately 75-80% are autosomal recessive, 10-20% autosomal dominant, 1-5% X-linked, and 0-2% mitochondrial. To date, 51 DFNA loci, 61 DFNB loci, and 7 DFN loci have been described. Non-syndromic hearing loss is divided into two postlingual and perlingual groups. As a general rule, most autosomal dominant non-syndromic hereditary hearing impaired is postlingual, while autosomal recessive non-syndromic hereditary hearing impaired is prelingual. |
| first_indexed | 2024-12-22T13:52:18Z |
| format | Article |
| id | doaj.art-b958a856be1040f095374270174033d2 |
| institution | Directory Open Access Journal |
| issn | 1607-2960 1607-2960 |
| language | fas |
| last_indexed | 2024-12-22T13:52:18Z |
| publishDate | 2005-04-01 |
| publisher | University of Social Welfare and Rehabilitation Sciences |
| record_format | Article |
| series | Journal of Rehabilitation |
| spelling | doaj.art-b958a856be1040f095374270174033d22022-12-21T18:23:38ZfasUniversity of Social Welfare and Rehabilitation SciencesJournal of Rehabilitation1607-29601607-29602005-04-01614856Review: Hearing Loss GeneticsHossein Najm-Abadi0Kimia Kahrizi1 University of Welfare & Rehabilitation Siences, Tehran, Iran. It has been estimated that approximately one in 1000 live births suffer from profound deafness, and greater than 50% of this group is genetic etiology. So far more than 300 different genetic conditions responsible for deafness have been reported that among them 70% are non-syndromic and the rest are syndromic. Non-syndromic and syndromic hearing loss may be divided into Autosomal dominant (DFNA), Autosomal recessive (DFNB), X-linked (DFN), and mitochondrial. Approximately 75-80% are autosomal recessive, 10-20% autosomal dominant, 1-5% X-linked, and 0-2% mitochondrial. To date, 51 DFNA loci, 61 DFNB loci, and 7 DFN loci have been described. Non-syndromic hearing loss is divided into two postlingual and perlingual groups. As a general rule, most autosomal dominant non-syndromic hereditary hearing impaired is postlingual, while autosomal recessive non-syndromic hereditary hearing impaired is prelingual.http://rehabilitationj.uswr.ac.ir/browse.php?a_code=A-10-1-99&slc_lang=en&sid=1Syndromic hearing loss Non-syndromic hearing loss Hereditary hearing impaired mutation Genetic |
| spellingShingle | Hossein Najm-Abadi Kimia Kahrizi Review: Hearing Loss Genetics Journal of Rehabilitation Syndromic hearing loss Non-syndromic hearing loss Hereditary hearing impaired mutation Genetic |
| title | Review: Hearing Loss Genetics |
| title_full | Review: Hearing Loss Genetics |
| title_fullStr | Review: Hearing Loss Genetics |
| title_full_unstemmed | Review: Hearing Loss Genetics |
| title_short | Review: Hearing Loss Genetics |
| title_sort | review hearing loss genetics |
| topic | Syndromic hearing loss Non-syndromic hearing loss Hereditary hearing impaired mutation Genetic |
| url | http://rehabilitationj.uswr.ac.ir/browse.php?a_code=A-10-1-99&slc_lang=en&sid=1 |
| work_keys_str_mv | AT hosseinnajmabadi reviewhearinglossgenetics AT kimiakahrizi reviewhearinglossgenetics |