Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Summary: Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The regulation of apoptosis is thought to be crucial for normal embryonic development. Accordingly, complete loss of pro-survival MCL-1 or...

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Bibliographic Details
Main Authors: Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718313342

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