THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITY
Background. To estimate the correlation of adipokines, cytokines, endothelial dysfunction markers and hemostasis with state of target organs in young patients with hypertension and abdominal obesity. Materials and methods. The blood content of adipokines, cytokines, endothelial dysfunction markers a...
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| Format: | Article |
| Language: | English |
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Science and Innovation Center Publishing House
2016-06-01
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| Series: | В мире научных открытий |
| Subjects: | |
| Online Access: | http://journal-s.org/index.php/vmno/article/view/9143 |
| _version_ | 1818440381297065984 |
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| author | Vasiliy Sergeevich Chulkov Veronika Andreevna Sumerkina Vladislav Sergeevich Chulkov |
| author_facet | Vasiliy Sergeevich Chulkov Veronika Andreevna Sumerkina Vladislav Sergeevich Chulkov |
| author_sort | Vasiliy Sergeevich Chulkov |
| collection | DOAJ |
| description | Background. To estimate the correlation of adipokines, cytokines, endothelial dysfunction markers and hemostasis with state of target organs in young patients with hypertension and abdominal obesity.
Materials and methods. The blood content of adipokines, cytokines, endothelial dysfunction markers and hemostasis in patients with hypertension, abdominal obesity and their combination was determined. Standard 12-lead ECG, two-dimensional echocardiography and duplex scanning of the brachiocephalic arteries were performed in all patients.
Results. In young patients with combination of hypertension and abdominal obesity were determined the increased levels of leptin, interleukin-6, monocyte chemoattractant protein type 1, endothelin, angiotensin II and prothrombotic changes in hemostasis. Among this patients were revealed hypertrophy of the left ventricle myocardium and increased intima-media complex thickness compared to those in groups with isolated hypertension, isolated abdominal obesity and the control group. The greatest diagnostic significance for predicting myocardial hypertrophy of the left ventricle according to the ROC-analysis were endothelin level >3,49 pg/ml and interleukin-6 level >5,67 pg/ml. |
| first_indexed | 2024-12-14T18:11:27Z |
| format | Article |
| id | doaj.art-b9593c3314b54b57ae9b821c430d7d66 |
| institution | Directory Open Access Journal |
| issn | 2072-0831 2307-9428 |
| language | English |
| last_indexed | 2024-12-14T18:11:27Z |
| publishDate | 2016-06-01 |
| publisher | Science and Innovation Center Publishing House |
| record_format | Article |
| series | В мире научных открытий |
| spelling | doaj.art-b9593c3314b54b57ae9b821c430d7d662022-12-21T22:52:17ZengScience and Innovation Center Publishing HouseВ мире научных открытий2072-08312307-94282016-06-0106647910.12731/wsd-2016-6-45557THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITYVasiliy Sergeevich Chulkov0Veronika Andreevna Sumerkina1Vladislav Sergeevich Chulkov2Южно-Уральский государственный медицинский университетЮжно-Уральский государственный медицинский университетЮжно-Уральский государственный медицинский университетBackground. To estimate the correlation of adipokines, cytokines, endothelial dysfunction markers and hemostasis with state of target organs in young patients with hypertension and abdominal obesity. Materials and methods. The blood content of adipokines, cytokines, endothelial dysfunction markers and hemostasis in patients with hypertension, abdominal obesity and their combination was determined. Standard 12-lead ECG, two-dimensional echocardiography and duplex scanning of the brachiocephalic arteries were performed in all patients. Results. In young patients with combination of hypertension and abdominal obesity were determined the increased levels of leptin, interleukin-6, monocyte chemoattractant protein type 1, endothelin, angiotensin II and prothrombotic changes in hemostasis. Among this patients were revealed hypertrophy of the left ventricle myocardium and increased intima-media complex thickness compared to those in groups with isolated hypertension, isolated abdominal obesity and the control group. The greatest diagnostic significance for predicting myocardial hypertrophy of the left ventricle according to the ROC-analysis were endothelin level >3,49 pg/ml and interleukin-6 level >5,67 pg/ml.http://journal-s.org/index.php/vmno/article/view/9143артериальная гипертензияабдоминальное ожирениецитокиныадипокиныдисфункция эндотелиягипертрофия миокарда левого желудочкатолщина комплекса интима-медиа |
| spellingShingle | Vasiliy Sergeevich Chulkov Veronika Andreevna Sumerkina Vladislav Sergeevich Chulkov THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITY В мире научных открытий артериальная гипертензия абдоминальное ожирение цитокины адипокины дисфункция эндотелия гипертрофия миокарда левого желудочка толщина комплекса интима-медиа |
| title | THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITY |
| title_full | THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITY |
| title_fullStr | THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITY |
| title_full_unstemmed | THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITY |
| title_short | THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITY |
| title_sort | estimate of adipokines cytokines markers of endothelial dysfunction and hemostasis correlation with the state of target organs in young patients with hypertension combined with abdominal obesity |
| topic | артериальная гипертензия абдоминальное ожирение цитокины адипокины дисфункция эндотелия гипертрофия миокарда левого желудочка толщина комплекса интима-медиа |
| url | http://journal-s.org/index.php/vmno/article/view/9143 |
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