Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia
ackground: Brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia. In this study, we tried to investigate the protein levels of BDNF and TrkB from peripheral blood in the veins...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-06-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.biomedj.org/article.asp?issn=2319-4170;year=2013;volume=36;issue=3;spage=132;epage=136;aulast=Hung |
| _version_ | 1828355460598595584 |
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| author | Yi-Yung Hung Tiao-Lai Huang |
| author_facet | Yi-Yung Hung Tiao-Lai Huang |
| author_sort | Yi-Yung Hung |
| collection | DOAJ |
| description | ackground: Brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia. In this study, we tried to investigate the protein levels of BDNF and TrkB from peripheral blood in the veins of individuals with schizophrenia and health controls.
Methods: From January 2008 to November 2010, we recruited 40 schizophrenic patients and 56 healthy controls. Serum BDNF and total TrkB protein levels were detected with enzyme-linked immunosorbent assay (ELISA) kits. Outliners of BDNF and TrkB were excluded initially. Analysis of covariance (ANCOVA) with age adjustment was used for group mean differences of different groups.
Results: After using the ANCOVA with age adjustment, the results of this work showed that BDNF presented no significant difference (F = 0.065, p = 0.800), but the serum TrkB protein level was significantly lower in schizophrenic patients than in healthy controls (F = 8.34, p = 0.005).
Conclusion: Our findings showed a lower TrkB protein level in serum from schizophrenia patients compared with healthy controls, indicating that the signaling transmission of BDNF/TrkB may be affected in peripheral blood from individuals with schizophrenia. |
| first_indexed | 2024-04-14T02:41:39Z |
| format | Article |
| id | doaj.art-b95bce65245a4ff39567fba5da872499 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 2320-2890 |
| language | English |
| last_indexed | 2024-04-14T02:41:39Z |
| publishDate | 2013-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-b95bce65245a4ff39567fba5da8724992022-12-22T02:16:54ZengElsevierBiomedical Journal2319-41702320-28902013-06-0136313213610.4103/2319-4170.113229Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with SchizophreniaYi-Yung Hung0Tiao-Lai Huang1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwanackground: Brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia. In this study, we tried to investigate the protein levels of BDNF and TrkB from peripheral blood in the veins of individuals with schizophrenia and health controls. Methods: From January 2008 to November 2010, we recruited 40 schizophrenic patients and 56 healthy controls. Serum BDNF and total TrkB protein levels were detected with enzyme-linked immunosorbent assay (ELISA) kits. Outliners of BDNF and TrkB were excluded initially. Analysis of covariance (ANCOVA) with age adjustment was used for group mean differences of different groups. Results: After using the ANCOVA with age adjustment, the results of this work showed that BDNF presented no significant difference (F = 0.065, p = 0.800), but the serum TrkB protein level was significantly lower in schizophrenic patients than in healthy controls (F = 8.34, p = 0.005). Conclusion: Our findings showed a lower TrkB protein level in serum from schizophrenia patients compared with healthy controls, indicating that the signaling transmission of BDNF/TrkB may be affected in peripheral blood from individuals with schizophrenia.http://www.biomedj.org/article.asp?issn=2319-4170;year=2013;volume=36;issue=3;spage=132;epage=136;aulast=Hungbrain-derived neurotrophic factorschizophreniatropomyosin receptor kinase B |
| spellingShingle | Yi-Yung Hung Tiao-Lai Huang Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia Biomedical Journal brain-derived neurotrophic factor schizophrenia tropomyosin receptor kinase B |
| title | Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia |
| title_full | Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia |
| title_fullStr | Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia |
| title_full_unstemmed | Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia |
| title_short | Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia |
| title_sort | lower serum tropomyosin receptor kinase b levels in patients with schizophrenia |
| topic | brain-derived neurotrophic factor schizophrenia tropomyosin receptor kinase B |
| url | http://www.biomedj.org/article.asp?issn=2319-4170;year=2013;volume=36;issue=3;spage=132;epage=136;aulast=Hung |
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