COMT Val158Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function

COMT Val158Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function

Evidence suggests that dopamine levels in the prefrontal cortex (PFC) modulate executive functions. A key regulator of PFC dopamine is catechol-O-methyltransferase (COMT). The activity level of the COMT enzyme are influenced by sex and the Val158Met polymorphism (rs4680) of the COMT gene, with male...

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Bibliographic Details
Main Authors: Amanda Elton, Christopher T. Smith, Michael H. Parrish, Charlotte A. Boettiger
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Human Neuroscience
Subjects:
fMRI
dopamine
COMT
delay discounting
sex differences
Online Access:http://journal.frontiersin.org/article/10.3389/fnhum.2017.00578/full

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