Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study
Objectives We aimed to evaluate whether obese patients with psoriatic arthritis (PsA) were less likely to be in remission/low disease activity (LDA).Methods We used data from the ReFlaP, an international multi-centre cohort study (NCT03119805), which recruited consecutive adults with definite PsA (d...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-07-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/9/3/e003157.full |
| _version_ | 1797640288862208000 |
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| author | Laure Gossec Ana-Maria Orbai Josef S Smolen Juan D Cañete Maarten de Wit Laura C Coates Uta Kiltz Penelope Palominos Rossana Scrivo Andra Balanescu Martin Soubrier Lihi Eder Umut Kalyoncu Emanuelle Dernis Ying Ying Leung Sandra Meisalu |
| author_facet | Laure Gossec Ana-Maria Orbai Josef S Smolen Juan D Cañete Maarten de Wit Laura C Coates Uta Kiltz Penelope Palominos Rossana Scrivo Andra Balanescu Martin Soubrier Lihi Eder Umut Kalyoncu Emanuelle Dernis Ying Ying Leung Sandra Meisalu |
| author_sort | Laure Gossec |
| collection | DOAJ |
| description | Objectives We aimed to evaluate whether obese patients with psoriatic arthritis (PsA) were less likely to be in remission/low disease activity (LDA).Methods We used data from the ReFlaP, an international multi-centre cohort study (NCT03119805), which recruited consecutive adults with definite PsA (disease duration ≥ 2 years) from 14 countries. Demographics, clinical data, comorbidities, and patient-reported outcomes were collected. Remission/LDA was defined as Very Low Disease Activity (VLDA)/minimal disease activity (MDA), Disease Activity in PSoriatic Arthritis (DAPSA) ≤4/≤14, or by patients’ opinion. Obesity was defined as physician-reported and/or body mass index ≥30 kg/m2. We evaluated the association between obesity and the presence of remission/LDA, with adjustment in multivariable regression models.Results Among 431 patients (49.3% women), 136 (31.6%) were obese. Obese versus non-obese patients were older, more frequently women, had higher tender joint and enthesitis counts and worse pain, physical function and health-related quality of life. Obese patients were less likely to be in VLDA; DAPSA remission and MDA, with adjusted ORs of 0.31 (95% CI 0.13 to 0.77); 0.39 (95% CI 0.19 to 0.80) and 0.61 (95% CI 0.38 to 0.99), respectively. Rates of DAPSA-LDA and patient-reported remission/LDA were similar for obese and non-obese patients.Conclusion PsA patients with comorbid obesity were 2.5–3 folds less likely to be in remission/LDA by composite scores compared with non-obese patients; however, remission/LDA rates were similar based on the patients’ opinion. PsA patients with comorbid obesity may have different disease profiles and require individualised management. |
| first_indexed | 2024-03-11T13:28:48Z |
| format | Article |
| id | doaj.art-b95f38d6eda64d57a56bd953230e4f5c |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-03-11T13:28:48Z |
| publishDate | 2023-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-b95f38d6eda64d57a56bd953230e4f5c2023-11-03T04:20:07ZengBMJ Publishing GroupRMD Open2056-59332023-07-019310.1136/rmdopen-2023-003157Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional studyLaure Gossec0Ana-Maria Orbai1Josef S Smolen2Juan D Cañete3Maarten de Wit4Laura C Coates5Uta Kiltz6Penelope Palominos7Rossana Scrivo8Andra Balanescu9Martin Soubrier10Lihi Eder11Umut Kalyoncu12Emanuelle Dernis13Ying Ying Leung14Sandra Meisalu15AP-HP, Rheumatology Department, Pitié-Salpêtrière Hospital, Paris, FranceMedicine Rheumatology, Johns Hopkins University, Baltimore, Maryland, USA2 Medical University of Vienna, Vienna, AustriaRheumatology Department, Hospital Clinic and Institut D`Investigacions Biomediques August Pi Sunyer, Barcelona, SpainPatient Research Partner, EULAR, Zaltbommel, The NetherlandsNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford and Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, UKRheumazentrum Ruhrgebiet, Herne and Ruhr-Universität Bochum, Bochum, GermanyDivision of Rheumatology, Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilRheumatology, Sapienza Università di Roma, Rome, ItalyDepartment of Internal Medicine and Rheumatology, ‘Sf. Maria’ Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaRheumatology, University Hospital Centre Gabriel Montpied, Clermont-Ferrand, FranceDepartment of Medicine, Women`s College Research Institute, University of Toronto, Toronto, Ontario, CanadaDepartment of Internal Medicine, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, TurkeyService de rhumatologie, Centre hospitalier Le Mans, Le Mans, FranceDepartment of Rheumatology & Immunology, Singapore General Hospital, SingaporeDepartment of Rheumatology, East Tallinn Central Hospital, Tallinn, EstoniaObjectives We aimed to evaluate whether obese patients with psoriatic arthritis (PsA) were less likely to be in remission/low disease activity (LDA).Methods We used data from the ReFlaP, an international multi-centre cohort study (NCT03119805), which recruited consecutive adults with definite PsA (disease duration ≥ 2 years) from 14 countries. Demographics, clinical data, comorbidities, and patient-reported outcomes were collected. Remission/LDA was defined as Very Low Disease Activity (VLDA)/minimal disease activity (MDA), Disease Activity in PSoriatic Arthritis (DAPSA) ≤4/≤14, or by patients’ opinion. Obesity was defined as physician-reported and/or body mass index ≥30 kg/m2. We evaluated the association between obesity and the presence of remission/LDA, with adjustment in multivariable regression models.Results Among 431 patients (49.3% women), 136 (31.6%) were obese. Obese versus non-obese patients were older, more frequently women, had higher tender joint and enthesitis counts and worse pain, physical function and health-related quality of life. Obese patients were less likely to be in VLDA; DAPSA remission and MDA, with adjusted ORs of 0.31 (95% CI 0.13 to 0.77); 0.39 (95% CI 0.19 to 0.80) and 0.61 (95% CI 0.38 to 0.99), respectively. Rates of DAPSA-LDA and patient-reported remission/LDA were similar for obese and non-obese patients.Conclusion PsA patients with comorbid obesity were 2.5–3 folds less likely to be in remission/LDA by composite scores compared with non-obese patients; however, remission/LDA rates were similar based on the patients’ opinion. PsA patients with comorbid obesity may have different disease profiles and require individualised management.https://rmdopen.bmj.com/content/9/3/e003157.full |
| spellingShingle | Laure Gossec Ana-Maria Orbai Josef S Smolen Juan D Cañete Maarten de Wit Laura C Coates Uta Kiltz Penelope Palominos Rossana Scrivo Andra Balanescu Martin Soubrier Lihi Eder Umut Kalyoncu Emanuelle Dernis Ying Ying Leung Sandra Meisalu Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study RMD Open |
| title | Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study |
| title_full | Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study |
| title_fullStr | Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study |
| title_full_unstemmed | Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study |
| title_short | Association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index-based and patient-based definitions of remission: a cross-sectional study |
| title_sort | association between obesity and likelihood of remission or low disease activity status in psoriatic arthritis applying index based and patient based definitions of remission a cross sectional study |
| url | https://rmdopen.bmj.com/content/9/3/e003157.full |
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